DRUM - Digital Repository at the University of Maryland

DRUM collects, preserves, and provides public access to the scholarly output of the university. Faculty and researchers can upload research products for rapid dissemination, global visibility and impact, and long-term preservation.

 
Submit to DRUM

Submit to DRUM

To submit an item to DRUM, login using your UMD credentials. Then select the "Submit Item to DRUM" link in the navigation bar. View DRUM policies and submission guidelines.
Equitable Access Policy

Equitable Access Policy

The University of Maryland Equitable Access Policy provides equitable, open access to the University's research and scholarship. Faculty can learn more about what is covered by the policy and how to deposit on the policy website.
Theses and Dissertations

Theses and Dissertations

DRUM includes all UMD theses and dissertations from 2003 forward.

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Recent Submissions

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Antimicrobial peptide class that forms discrete beta-barrel stable pores anchored by transmembrane helices
(Nature Communications, 2025-06) Dickey, Seth W.; Burgin, Dylan J.; Antwi, Ama N.; Villaruz, Amer; Galac, Madeline R.; Cheung, Gordon Y. C.; Rostovtseva, Tatiana K.; Worrall, Liam J.; Lazarski, Aleksander C.; Cino, Elio A.; Tieleman, D. Peter; Bezrukov, Sergey M.; Strynadka, Natalie C. J.; Otto, Michael; Dickey, Seth; Otto, Michael
Bacteriocins are weapons of inter-bacterial warfare and belong to the larger group of antimicrobial peptides (AMPs), which are frequently proposed as alternatives to antibiotics. Many AMPs kill by destroying the target’s cytoplasmic membrane using short-lived membrane perturbation. Contrastingly, protein toxins form large pores by stably assembling in the target membrane. Here we describe an AMP family we termed TMcins (for transmembrane helix-containing bacteriocin), in which half of the AMP forms a transmembrane helix. This characteristic allows TMcin to assemble into stable and large oligomeric pores. The biosynthetic locus of TMcin, which was broadly active against Gram-positive bacteria, is distributed throughout two major bacterial phyla, yet bears no homology to previously reported bacteriocin biosynthetic gene clusters. Our discovery of an AMP class that achieves pore stability otherwise only found in protein toxins transforms our current understanding of AMP structure and function and underscores the continuing importance of phenotype-initiated investigations in uncovering wholly uncharacterized antimicrobials.
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Charting New Courses: Navigating, Designing, and Facilitating Archival Instruction
(2025-05) Summerbell, Samantha
This presentation was given as part of Session 7 "Archival Educators in MARAC: Building the Bridges Between Theory & Practice" at the Spring 2025 MARAC conference in Harrisburg, PA.
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Building a Community of Care in Archival Education
(2025-05) Elia, Marie
This presentation was given as part of Session 7 "Archival Educators in MARAC: Building Bridges Between Theory & Practice" at the Spring 2025 MARAC conference in Harrisburg, PA.
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Program for the Spring 2025 MARAC Conference: Crossroads and Bridges in Archival Practice
(2025-05) MARAC: Mid-Atlantic Regional Archives Conference
The program for the spring 2025 MARAC conference "Crossroads and Bridges in Archival Practice," held in Harrisburg, PA May 1-3.
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Evaluating the Effectiveness of Economic Incentives to Enhance Riparian Buffer Adoption and Environmental Benefits for Water Quality and Carbon Sequestration in Maryland
(2024-10) Newburn, David; Lichtenberg, Erik; Kim, Youngho; Wietelman, Derek; Wang, Haoluan
This report assesses the effectiveness of economic incentives in encouraging Maryland farmers to adopt riparian buffers for improved water quality and carbon sequestration. Using a statewide landowner survey and integrated environmental-economic modeling, the study evaluates program design features such as payment type, contract length, and targeting. Results show that upfront payments increase participation, targeted bonuses improve cost-effectiveness, and carbon offset payments offer limited added benefit. Policy recommendations focus on enhancing program efficiency through strategic incentive design.