Alternatively activated lung alveolar and interstitial macrophages promote fungal growth

dc.contributor.authorStrickland, Ashley B.
dc.contributor.authorChen, Yanli
dc.contributor.authorSun, Donglei
dc.contributor.authorShi, Meiqing
dc.date.accessioned2024-06-06T14:53:35Z
dc.date.available2024-06-06T14:53:35Z
dc.date.issued2023-05-19
dc.descriptionPartial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.
dc.description.abstractHow lung macrophages, especially interstitial macrophages (IMs), respond to invading pathogens remains elusive. Here, we show that mice exhibited a rapid and substantial expansion of macrophages, especially CX3CR1+ IMs, in the lung following infection with Cryptococcus neoformans, a pathogenic fungus leading to high mortality among patients with HIV/AIDS. The IM expansion correlated with enhanced CSF1 and IL-4 production and was affected by the deficiency of CCR2 or Nr4a1. Both alveolar macrophages (AMs) and IMs were observed to harbor C. neoformans and became alternatively activated following infection, with IMs being more polarized. The absence of AMs by genetically disrupting CSF2 signaling reduced fungal loads in the lung and prolonged the survival of infected mice. Likewise, infected mice depleted of IMs by the CSF1 receptor inhibitor PLX5622 displayed significantly lower pulmonary fungal burdens. Thus, C. neoformans infection induces alternative activation of both AMs and IMs, which facilitates fungal growth in the lung.
dc.description.urihttps://doi.org/10.1016/j.isci.2023.106717
dc.identifierhttps://doi.org/10.13016/tmby-c5fd
dc.identifier.citationStrickland, A. B., Chen, Y., Sun, D., & Shi, M. (2023). Alternatively activated lung alveolar and interstitial macrophages promote fungal growth. iScience, 26(5), 106717.
dc.identifier.urihttp://hdl.handle.net/1903/32592
dc.publisherElsevier
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtDepartment of Veterinary Medicineen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectbiological sciences
dc.subjectimmunology
dc.subjectmycology
dc.subjectcell biology
dc.titleAlternatively activated lung alveolar and interstitial macrophages promote fungal growth
dc.typeArticle
local.equitableAccessSubmissionNo

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