Localizing Chemotherapeutic Drug Release to Treat Stage III Colorectal Cancer

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dc.contributor.advisorKofinas, Peter
dc.contributor.advisorAyyub, Omar
dc.contributor.authorSebastian, Ria
dc.contributor.authorAtalla, Anthony
dc.contributor.authorColey, Morgan
dc.contributor.authorHamers, Matthew
dc.contributor.authorTiberino, Matthew
dc.contributor.authorNagler, Matthew
dc.contributor.authorNassar, Yomna
dc.contributor.authorNichols, Alison
dc.contributor.authorMinahan, Eva
dc.contributor.authorKarodeh, Nima
dc.contributor.authorMcGrath, Jennifer
dc.contributor.authorWendeu-Foyet, Kevin
dc.date.accessioned2020-04-23T14:35:19Z
dc.date.available2020-04-23T14:35:19Z
dc.date.issued2020
dc.description.abstractThese studies focused on the incorporation of chemotherapeutic drugs into biodegradable polymers, specifically poly(lactide-co-caprolactone) (PLCL), as a localized form of cancer treatment. In conjunction with the surgical resection of a tumor, this polymer can be used to deposit drugs directly at the site and minimize the risks posed by systemic chemotherapy. The methodology focused on Stage IIIA colorectal cancer due to its high recurrence rate and the common use of surgery as a form of treatment. In our experiments, data was collected to compare the various physical, chemical, and mechanical properties between PLCL fiber mats loaded with Capecitabine in order to evaluate the most ideal drug release pattern. Results found that the combinations we had tested thus far had shown a delayed release, meaning at least a week passed before initial drug dissociation from the polymer. Current results suggest a possible relationship between molecular weight and the delay period length, which has implications in future research. Different polymers will also be studied to assess the chemical impact on the release patterns we found in our data.en_US
dc.description.sponsorshipThe Do Good Institute, The Great Foundation, LaunchUMD donors, Gemstone Honors College, Kofinas Laben_US
dc.identifierhttps://doi.org/10.13016/ixuo-txax
dc.identifier.urihttp://hdl.handle.net/1903/25840
dc.language.isoen_USen_US
dc.relation.isAvailableAtMaryland Center for Undergraduate Research
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.subjectbioengineeringen_US
dc.subjectENGRen_US
dc.subjectTeam TUMORen_US
dc.subjectGemstoneen_US
dc.subjectPolymeren_US
dc.subjectLocalized Chemotherapyen_US
dc.subjectStage III Colorectal Canceren_US
dc.titleLocalizing Chemotherapeutic Drug Release to Treat Stage III Colorectal Canceren_US
dc.typePresentationen_US

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