Localizing Chemotherapeutic Drug Release to Treat Stage III Colorectal Cancer


These studies focused on the incorporation of chemotherapeutic drugs into biodegradable polymers, specifically poly(lactide-co-caprolactone) (PLCL), as a localized form of cancer treatment. In conjunction with the surgical resection of a tumor, this polymer can be used to deposit drugs directly at the site and minimize the risks posed by systemic chemotherapy. The methodology focused on Stage IIIA colorectal cancer due to its high recurrence rate and the common use of surgery as a form of treatment. In our experiments, data was collected to compare the various physical, chemical, and mechanical properties between PLCL fiber mats loaded with Capecitabine in order to evaluate the most ideal drug release pattern. Results found that the combinations we had tested thus far had shown a delayed release, meaning at least a week passed before initial drug dissociation from the polymer. Current results suggest a possible relationship between molecular weight and the delay period length, which has implications in future research. Different polymers will also be studied to assess the chemical impact on the release patterns we found in our data.