A pilot comparison of first morning versus 24-hour urinary deoxynivalenol in UK adults

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dc.contributor.advisorTurner, Paulen_US
dc.contributor.authorBoonchaisri, Natalieen_US
dc.contributor.departmentMaryland Institute for Applied Environmental Healthen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2017-09-13T05:36:10Z
dc.date.available2017-09-13T05:36:10Z
dc.date.issued2017en_US
dc.description.abstractUsing unpublished data from an original study by Turner et al. (2010a), the relationship between first morning void (FMV) and 24-hour urine collections was examined in UK adults to determine if FMV collections provide a reasonable estimate of DON intake compared to 24-hour collections. The intraclass correlation coefficient (ICC) was computed to evaluate variability in DON concentrations and generalized estimating equation (GEE) models were used to assess the relationship between collection types. Greater between-person variability was observed in 24-hour collections, unadjusted and adjusted for creatinine (ICC=0.78 and 0.56, respectively). GEE models suggest urinary DON concentrations in FMV collections were strongly correlated with 24-hour collections (r=0.78, p<0.0001), meaning FMV collections may provide just as reasonable an estimate of DON intake compared to 24-hour collections when adjusting for age, sex, and BMI. These results strengthen the methodology behind exposure biomarkers and urinary assays when estimating DON intake.en_US
dc.identifierhttps://doi.org/10.13016/M2TQ5RF1N
dc.identifier.urihttp://hdl.handle.net/1903/19805
dc.language.isoenen_US
dc.subject.pqcontrolledEnvironmental healthen_US
dc.subject.pquncontrolleddeoxynivalenolen_US
dc.subject.pquncontrolledFMVen_US
dc.subject.pquncontrolledmycotoxinsen_US
dc.subject.pquncontrolledurinary biomarkersen_US
dc.titleA pilot comparison of first morning versus 24-hour urinary deoxynivalenol in UK adultsen_US
dc.typeThesisen_US

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