Enhancing anti-tumor immunity through local gene delivery to lymph nodes

Simple item page
dc.contributor.authorDold, Neil M
dc.contributor.authorJewell, Christopher M
dc.date.accessioned2021-08-17T15:32:25Z
dc.date.available2021-08-17T15:32:25Z
dc.date.issued2015-11-04
dc.description.abstractBiodegradable polymer carriers offer attractive features for therapeutic cancer vaccines including delivery of multiple vaccine components, efficient internalization, and sustained release of adjuvants and tumor-associated antigens (TAAs). We previously demonstrated that local delivery of depots containing nucleic acid-based toll-liked receptor agonists (TLRas) to lymph nodes (LNs) potently enhances antigen-specific T cell immunity. Building on this work, we hypothesized that local LN delivery of microparticles loaded with TAA-encoding plasmid DNA (pDNA) and TLRas might drive strong local expression and presentation of antigen by LN-resident antigen presenting cells. These effects could help drive more potent and effective CD8+ T cell functions that slow or stop tumor growth.
dc.description.urihttps://doi.org/10.1186/2051-1426-3-S2-P431
dc.identifierhttps://doi.org/10.13016/dnjv-geo3
dc.identifier.citationDold, N.M., Jewell, C.M. Enhancing anti-tumor immunity through local gene delivery to lymph nodes. j. immunotherapy cancer 3, P431 (2015).en_US
dc.identifier.urihttp://hdl.handle.net/1903/27616
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtA. James Clark School of Engineeringen_us
dc.relation.isAvailableAtFischell Department of Bioengineeringen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectVaccine Componenten_US
dc.subjectDendritic Cell Activationen_US
dc.subjectMurine Splenocytesen_US
dc.subjectAssess Gene Expressionen_US
dc.subjectTherapeutic Cancer Vaccineen_US
dc.titleEnhancing anti-tumor immunity through local gene delivery to lymph nodesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2051-1426-3-S2-P431.pdf
Size:
210.72 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.57 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Fischell Department of Bioengineering Research Works