Interferon Induction by RNA Viruses and Antagonism by Viral Pathogens

dc.contributor.authorNan, Yuchen
dc.contributor.authorNan, Guoxin
dc.contributor.authorZhang, Yan-Jin
dc.date.accessioned2024-01-23T17:16:54Z
dc.date.available2024-01-23T17:16:54Z
dc.date.issued2014-12-12
dc.description.abstractInterferons are a group of small proteins that play key roles in host antiviral innate immunity. Their induction mainly relies on host pattern recognition receptors (PRR). Host PRR for RNA viruses include Toll-like receptors (TLR) and retinoic acid-inducible gene I (RIG-I) like receptors (RLR). Activation of both TLR and RLR pathways can eventually lead to the secretion of type I IFNs, which can modulate both innate and adaptive immune responses against viral pathogens. Because of the important roles of interferons, viruses have evolved multiple strategies to evade host TLR and RLR mediated signaling. This review focuses on the mechanisms of interferon induction and antagonism of the antiviral strategy by RNA viruses.
dc.description.urihttps://doi.org/10.3390/v6124999
dc.identifierhttps://doi.org/10.13016/dspace/hndu-u6yn
dc.identifier.citationNan, Y.; Nan, G.; Zhang, Y.-J. Interferon Induction by RNA Viruses and Antagonism by Viral Pathogens. Viruses 2014, 6, 4999-5027.
dc.identifier.urihttp://hdl.handle.net/1903/31587
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtDepartment of Veterinary Medicineen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectinterferon induction
dc.subjectTLR
dc.subjectRLR
dc.subjectviral antagonism
dc.titleInterferon Induction by RNA Viruses and Antagonism by Viral Pathogens
dc.typeArticle
local.equitableAccessSubmissionNo

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