Anaphylatoxin signaling activates macrophages to control intracellular Rickettsia proliferation
dc.contributor.author | Dahmani, Mustapha | |
dc.contributor.author | Zhu, Jinyi C. | |
dc.contributor.author | Cook, Jack H. | |
dc.contributor.author | Riley, Sean P. | |
dc.date.accessioned | 2024-06-06T14:56:00Z | |
dc.date.available | 2024-06-06T14:56:00Z | |
dc.date.issued | 2023-10 | |
dc.description | Partial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund. | |
dc.description.abstract | Pathogenic Rickettsia species proliferate within the cytoplasm of permissive host cells in vivo. The cytoplasm of these host cells is adequate to support the complex metabolic and physiological needs for Rickettsia growth. However, a dramatic host/pathogen interplay occurs when Rickettsia encounter innate immune cells, whereby the bacteria can proliferate as normal or the host can restrict bacterial growth. This interplay is most divergent within myeloid host cells, where intra- and extracellular factors can produce either successful Rickettsia parasitism or innate immune control of bacterial proliferation. With the prior knowledge that the mammalian complement system is activated during mammalian infection, we sought to determine if extracellular complement activation and anaphylatoxin signaling can modify the fate of Rickettsia within mononuclear host cells. Results indicate that supplementation of growth media with either C3a or C5a anaphylatoxin peptides is sufficient for many myeloid cells to control the proliferation of multiple different Rickettsia species. Chemical or genetic disruption of anaphylatoxin signaling or anaphylatoxin receptors eliminates complement-induced restriction of bacterial proliferation. Finally, anaphylatoxin signaling modifies macrophage physiology by inducing inflammatory phenotypes that ultimately control the intracellular proliferation of these pathogens. | |
dc.description.uri | https://doi.org/10.1128/spectrum.02538-23 | |
dc.identifier | https://doi.org/10.13016/aipa-tome | |
dc.identifier.citation | Dahmani M, Zhu JC, Cook JH, Riley SP. 2023. Anaphylatoxin signaling activates macrophages to control intracellular Rickettsia proliferation. Microbiol Spectr 11:e02538-23. | |
dc.identifier.uri | http://hdl.handle.net/1903/32597 | |
dc.language.iso | en_US | |
dc.publisher | American Society for Microbiology | |
dc.relation.isAvailableAt | College of Agriculture & Natural Resources | en_us |
dc.relation.isAvailableAt | Department of Veterinary Medicine | en_us |
dc.relation.isAvailableAt | Digital Repository at the University of Maryland | en_us |
dc.relation.isAvailableAt | University of Maryland (College Park, MD) | en_us |
dc.title | Anaphylatoxin signaling activates macrophages to control intracellular Rickettsia proliferation | |
dc.type | Article | |
local.equitableAccessSubmission | No |
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