Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines

dc.contributor.authorKim, Shin-Hee
dc.contributor.authorSamal, Siba K.
dc.date.accessioned2023-11-16T18:16:31Z
dc.date.available2023-11-16T18:16:31Z
dc.date.issued2019-03-26
dc.description.abstractHighly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry. Live attenuated Newcastle disease virus (NDV) vectored vaccines have been developed for bivalent vaccination against HPAI viruses and NDV. These vaccines have been generated by inserting the hemagglutinin (HA) gene of avian influenza virus into NDV genomes. In laboratory settings, several experimental NDV-vectored vaccines have protected specific pathogen-free chickens from mortality, clinical signs, and virus shedding against H5 and H7 HPAI viruses and NDV challenges. NDV-vectored H5 vaccines have been licensed for poultry vaccination in China and Mexico. Recently, an antigenically chimeric NDV vector has been generated to overcome pre-existing immunity to NDV in poultry and to provide early protection of poultry in the field. Prime immunization of one-day-old poults with a chimeric NDV vector followed by boosting with a conventional NDV vector has shown to protect broiler chickens against H5 HPAI viruses and a highly virulent NDV. This novel vaccination approach can provide efficient control of HPAI viruses in the field and facilitate poultry vaccination.
dc.description.urihttps://doi.org/10.3390/v11030300
dc.identifierhttps://doi.org/10.13016/dspace/dd87-5von
dc.identifier.citationKim, S.-H.; Samal, S.K. Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines. Viruses 2019, 11, 300.
dc.identifier.urihttp://hdl.handle.net/1903/31421
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtDepartment of Veterinary Medicineen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjecthighly pathogenic avian influenza virus
dc.subjectNewcastle disease virus
dc.subjectlive attenuated NDV-vectored vaccines
dc.subjectchimeric NDV vector
dc.subjectpoultry
dc.titleInnovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines
dc.typeArticle
local.equitableAccessSubmissionNo

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