Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines

dc.contributor.authorKim, Shin-Hee
dc.contributor.authorSamal, Siba K.
dc.date.accessioned2023-12-05T14:52:13Z
dc.date.available2023-12-05T14:52:13Z
dc.date.issued2016-07-04
dc.description.abstractViral vaccine vectors have shown to be effective in inducing a robust immune response against the vaccine antigen. Newcastle disease virus (NDV), an avian paramyxovirus, is a promising vaccine vector against human and veterinary pathogens. Avirulent NDV strains LaSota and B1 have long track records of safety and efficacy. Therefore, use of these strains as vaccine vectors is highly safe in avian and non-avian species. NDV replicates efficiently in the respiratory track of the host and induces strong local and systemic immune responses against the foreign antigen. As a vaccine vector, NDV can accommodate foreign sequences with a good degree of stability and as a RNA virus, there is limited possibility for recombination with host cell DNA. Using NDV as a vaccine vector in humans offers several advantages over other viral vaccine vectors. NDV is safe in humans due to host range restriction and there is no pre-existing antibody to NDV in the human population. NDV is antigenically distinct from common human pathogens. NDV replicates to high titer in a cell line acceptable for human vaccine development. Therefore, NDV is an attractive vaccine vector for human pathogens for which vaccines are currently not available. NDV is also an attractive vaccine vector for animal pathogens.
dc.description.urihttps://doi.org/10.3390/v8070183
dc.identifierhttps://doi.org/10.13016/dspace/u14z-ko2p
dc.identifier.citationKim, S.-H.; Samal, S.K. Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines. Viruses 2016, 8, 183.
dc.identifier.urihttp://hdl.handle.net/1903/31529
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtDepartment of Veterinary Medicineen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectNewcastle disease virus
dc.subjectvaccine vector
dc.subjecthuman vaccines
dc.subjectveterinary vaccines
dc.titleNewcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines
dc.typeArticle
local.equitableAccessSubmissionNo

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