Comparative transcriptome in large-scale human and cattle populations

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dc.contributor.authorYao, Yuelin
dc.contributor.authorLiu, Shuli
dc.contributor.authorXia, Charley
dc.contributor.authorGao, Yahui
dc.contributor.authorPan, Zhangyuan
dc.contributor.authorCanela-Xandri, Oriol
dc.contributor.authorKhamseh, Ava
dc.contributor.authorRawlik, Konrad
dc.contributor.authorWang, Sheng
dc.contributor.authorLi, Bingjie
dc.contributor.authorZhang, Yi
dc.contributor.authorPairo-Castineira, Erola
dc.contributor.authorD’Mellow, Kenton
dc.contributor.authorLi, Xiujin
dc.contributor.authorYan, Ze
dc.contributor.authorLi, Cong-jun
dc.contributor.authorYu, Ying
dc.contributor.authorZhang, Shengli
dc.contributor.authorMa, Li
dc.contributor.authorCole, John B.
dc.contributor.authorRoss, Pablo J.
dc.contributor.authorZhou, Huaijun
dc.contributor.authorHaley, Chris
dc.contributor.authorLiu, George E.
dc.contributor.authorFang, Lingzhao
dc.contributor.authorTenesa, Albert
dc.date.accessioned2022-09-12T16:38:18Z
dc.date.available2022-09-12T16:38:18Z
dc.date.issued2022-08-22
dc.description.abstractCross-species comparison of transcriptomes is important for elucidating evolutionary molecular mechanisms underpinning phenotypic variation between and within species, yet to date it has been essentially limited to model organisms with relatively small sample sizes. Here, we systematically analyze and compare 10,830 and 4866 publicly available RNA-seq samples in humans and cattle, respectively, representing 20 common tissues. Focusing on 17,315 orthologous genes, we demonstrate that mean/median gene expression, inter-individual variation of expression, expression quantitative trait loci, and gene co-expression networks are generally conserved between humans and cattle. By examining large-scale genome-wide association studies for 46 human traits (average n = 327,973) and 45 cattle traits (average n = 24,635), we reveal that the heritability of complex traits in both species is significantly more enriched in transcriptionally conserved than diverged genes across tissues. In summary, our study provides a comprehensive comparison of transcriptomes between humans and cattle, which might help decipher the genetic and evolutionary basis of complex traits in both species.en_US
dc.description.urihttps://doi.org/10.1186/s13059-022-02745-4
dc.identifierhttps://doi.org/10.13016/isvr-pu4f
dc.identifier.citationYao, Y., Liu, S., Xia, C. et al. Comparative transcriptome in large-scale human and cattle populations. Genome Biol 23, 176 (2022).en_US
dc.identifier.urihttp://hdl.handle.net/1903/29119
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtAnimal & Avian Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.titleComparative transcriptome in large-scale human and cattle populationsen_US
dc.typeArticleen_US

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