Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation

dc.contributor.authorNan, Yuchen
dc.contributor.authorWu, Chunyan
dc.contributor.authorZhang, Yan-Jin
dc.date.accessioned2023-11-20T21:39:52Z
dc.date.available2023-11-20T21:39:52Z
dc.date.issued2018-04-14
dc.description.abstractInterferons (IFNs) are a group of secreted proteins that play critical roles in antiviral immunity, antitumor activity, activation of cytotoxic T cells, and modulation of host immune responses. IFNs are cytokines, and bind receptors on cell surfaces to trigger signal transduction. The major signaling pathway activated by IFNs is the JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathway, a complex pathway involved in both viral and host survival strategies. On the one hand, viruses have evolved strategies to escape from antiviral host defenses evoked by IFN-activated JAK/STAT signaling. On the other hand, viruses have also evolved to exploit the JAK/STAT pathway to evoke activation of certain STATs that somehow promote viral pathogenesis. In this review, recent progress in our understanding of the virus-induced IFN-independent STAT signaling and its potential roles in viral induced inflammation and pathogenesis are summarized in detail, and perspectives are provided.
dc.description.urihttps://doi.org/10.3390/v10040196
dc.identifierhttps://doi.org/10.13016/dspace/bwhz-wwfd
dc.identifier.citationNan, Y.; Wu, C.; Zhang, Y.-J. Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation. Viruses 2018, 10, 196.
dc.identifier.urihttp://hdl.handle.net/1903/31466
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtDepartment of Veterinary Medicineen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectInterferons
dc.subjectJAK/STAT signaling
dc.subjectnon-canonical STAT activation
dc.subjectviral antagonism
dc.subjectinflammation
dc.titleInterferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation
dc.typeArticle
local.equitableAccessSubmissionNo

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