IMPROVED INFECTIOUS LARYNGOTRACHEITIS VIRUS VACCINES USING NEWCASTLE DISEASE VIRUS VECTOR

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dc.contributor.advisorSamal, Siba Ken_US
dc.contributor.authorKanabagatte Basavarajappa, Mallikarjunaen_US
dc.contributor.departmentVeterinary Medical Scienceen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2013-06-29T05:37:09Z
dc.date.available2013-06-29T05:37:09Z
dc.date.issued2013en_US
dc.description.abstractInfectious laryngotracheitis (ILT) is a highly contagious acute respiratory disease of chickens for which safe and efficacious vaccines are not available currently. In the present study, we have generated three recombinant Newcastle disease viruses (rNDV's) expressing three major envelope glycoproteins gB, gC and gD of ILTV individually. A single oculonasal inoculation of chickens with rNDV's elicited detectable level of systemic antibodies specific to ILTV. Following challenge with virulent strain of ILTV, chickens immunized with the rNDV's displayed partial protection with reduced clinical signs and shorter duration of disease compared to the control group. Our data suggested that NDV vectored ILTV vaccines are useful against ILTV infection, but might require augmentation by a second dose or require modification of ILTV glycoproteins which allow them to incorporate into the mature rNDV virions for better induction of humoral and cell mediated immune responses.en_US
dc.identifier.urihttp://hdl.handle.net/1903/14174
dc.subject.pqcontrolledVeterinary medicineen_US
dc.subject.pqcontrolledVirologyen_US
dc.subject.pquncontrolledGlycoprotein Ben_US
dc.subject.pquncontrolledGlycoprotein Cen_US
dc.subject.pquncontrolledGlycoprotein Den_US
dc.subject.pquncontrolledInfectious laryngotracheitisen_US
dc.subject.pquncontrolledNewcastle disease virusen_US
dc.subject.pquncontrolledViral vectored vaccines for ILTen_US
dc.titleIMPROVED INFECTIOUS LARYNGOTRACHEITIS VIRUS VACCINES USING NEWCASTLE DISEASE VIRUS VECTORen_US
dc.typeThesisen_US

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