Role of Host Cell Secretory Machinery in Zika Virus Life Cycle

dc.contributor.authorSager, Garrett
dc.contributor.authorGabaglio, Samuel
dc.contributor.authorSztul, Elizabeth
dc.contributor.authorBelov, George A.
dc.date.accessioned2023-11-20T19:43:49Z
dc.date.available2023-11-20T19:43:49Z
dc.date.issued2018-10-15
dc.description.abstractThe high human cost of Zika virus infections and the rapid establishment of virus circulation in novel areas, including the United States, present an urgent need for countermeasures against this emerging threat. The development of an effective vaccine against Zika virus may be problematic because of the cross reactivity of the antibodies with other flaviviruses leading to antibody-dependent enhancement of infection. Moreover, rapidly replicating positive strand RNA viruses, including Zika virus, generate large spectrum of mutant genomes (quasi species) every replication round, allowing rapid selection of variants resistant to drugs targeting virus-specific proteins. On the other hand, viruses are ultimate cellular parasites and rely on the host metabolism for every step of their life cycle, thus presenting an opportunity to manipulate host processes as an alternative approach to suppress virus replication and spread. Zika and other flaviviruses critically depend on the cellular secretory pathway, which transfers proteins and membranes from the ER through the Golgi to the plasma membrane, for virion assembly, maturation and release. In this review, we summarize the current knowledge of interactions of Zika and similar arthropod-borne flaviviruses with the cellular secretory machinery with a special emphasis on virus-specific changes of the secretory pathway. Identification of the regulatory networks and effector proteins required to accommodate the trafficking of virions, which represent a highly unusual cargo for the secretory pathway, may open an attractive and virtually untapped reservoir of alternative targets for the development of superior anti-viral drugs.
dc.description.urihttps://doi.org/10.3390/v10100559
dc.identifierhttps://doi.org/10.13016/dspace/886p-tlbu
dc.identifier.citationSager, G.; Gabaglio, S.; Sztul, E.; Belov, G.A. Role of Host Cell Secretory Machinery in Zika Virus Life Cycle. Viruses 2018, 10, 559.
dc.identifier.urihttp://hdl.handle.net/1903/31447
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtDepartment of Veterinary Medicineen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectZika virus
dc.subjectflaviviruses
dc.subjectvirion maturation
dc.subjectsecretory pathway
dc.subjectmembrane trafficking
dc.titleRole of Host Cell Secretory Machinery in Zika Virus Life Cycle
dc.typeArticle
local.equitableAccessSubmissionNo

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