MagnetoStalsis: Generating Peristalsis in an Artificial Bowel for Treatment of Short Bowel Syndrome

Abstract

Efforts to develop an artificial intestine for treatment of short bowel syndrome have thus far failed to achieve coordinated peristalsis. To address this, we introduce an implantable, biomimetic, magnetically-actuated peristaltic pumping apparatus. The system consists of a magnetic pump surrounding an intestinal graft and a rotating external magnetic field generator that produces peristaltic motion in the graft as the field direction alternates. We performed computational finite element modeling to simulate deformation and stress concentration on the pump. We then tested the ability of the system to produce fluid flow through porcine subintestinal submucosa at actuation frequencies from 0 to 4 Hz. The system achieved a maximal flow rate of 6.03 mL/min at 3 Hz actuation frequency, which is in the physiological range of human intestinal flow rates. This device represents a novel proof-of-concept for achieving untethered peristalsis in an implantable intestinal graft that is primed for preclinical testing in animal models of short bowel syndrome.