Understanding the Relevance of Extended Amygdala Reactivity to Dispositional Negativity

Simple item page
dc.contributor.advisorShackman, Alexander Jen_US
dc.contributor.authorGrogans, Shannon Elizabethen_US
dc.contributor.departmentPsychologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2021-09-17T05:31:51Z
dc.date.available2021-09-17T05:31:51Z
dc.date.issued2021en_US
dc.description.abstractElevated dispositional negativity (DN; i.e., neuroticism/negative emotionality) is associated with a range of deleterious outcomes, including mental illness. Yet, DN’s neurobiology remains incompletely understood. Prior work suggests that DN reflects heightened threat-elicited reactivity in the extended amygdala (EAc), a circuit encompassing the central nucleus (Ce) and the bed nucleus of the stria terminalis (BST), and that this association may be intensified for uncertain threat. We utilized a multi-trait, multi-occasion DN composite and neuroimaging assays of threat anticipation and perception to demonstrate that individuals with elevated DN show heightened BST activation during threat anticipation. Analyses revealed that DN is uniquely predicted by BST reactivity to uncertain threat. DN was unrelated to Ce activation during threat anticipation or EAc activation during ‘threatening’-face presentation. Follow-up analyses revealed that the threat paradigms are not interchangeable probes of EAc function. These observations lay the foundation for future studies necessary to determine causation and improve interventions.en_US
dc.identifierhttps://doi.org/10.13016/moro-w6i8
dc.identifier.urihttp://hdl.handle.net/1903/27789
dc.language.isoenen_US
dc.subject.pqcontrolledClinical psychologyen_US
dc.subject.pqcontrolledNeurosciencesen_US
dc.subject.pquncontrolledAffective Neuroscienceen_US
dc.subject.pquncontrolledAmygdalaen_US
dc.subject.pquncontrolledFear and Anxietyen_US
dc.subject.pquncontrolledIndividual Differencesen_US
dc.subject.pquncontrolledNeuroimagingen_US
dc.subject.pquncontrolledNeuroticismen_US
dc.titleUnderstanding the Relevance of Extended Amygdala Reactivity to Dispositional Negativityen_US
dc.typeThesisen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Grogans_umd_0117N_21806.pdf
Size:
2 MB
Format:
Adobe Portable Document Format
Download

Collections

UMD Theses and Dissertations
Psychology Theses and Dissertations