INTERACTIONS BETWEEN SEROTONIN AND BEHAVIORAL SENSITIVITY TO ACUTE ALCOHOL EXPOSURE IN CRAYFISH

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dc.contributor.advisorHerberholz, Jensen_US
dc.contributor.authorHo, Tawenen_US
dc.contributor.departmentNeuroscience and Cognitive Scienceen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2022-02-04T06:41:52Z
dc.date.available2022-02-04T06:41:52Z
dc.date.issued2021en_US
dc.description.abstractSocial isolation has been found to correlate with an increase in alcohol consumption in humans. However, neurobehavioral and neurocellular mechanisms underlying interactions between alcohol and social isolation have been understudied. Prior work has shown that socially isolated crayfish exhibit lower behavioral and neural sensitivity to acute ethanol (EtOH) exposure than communally-housed conspecifics. Here we report an important role of the serotonergic system in mediating this socially-dependent effect. We found that depletion of serotonin (5-HT) from serotonergic neurons reduced behavioral sensitivity to EtOH, but the effect was more pronounced in communally housed animals. In addition, antagonizing 5-HT2β receptors also reduced EtOH sensitivity, and more strongly in group-housed animals, suggesting a possible down-regulation of 5-HT2β receptors in isolates. Pre-treatment with a selective serotonin reuptake inhibitor (fluoxetine) produced opposite modulatory effects, affirming the role of 5-HT in shaping the interactions between social experience and EtOH sensitivity. Thus, we show here, for the first time, that behavioral sensitivity to acute EtOH (i.e., intoxication) in crayfish is partially mediated by 5-HT, and our results suggest specific 5-HT receptor subtypes as possible targets for these interactions. This work might have relevance for studying the neurochemical mechanisms underlying the interplay between social history and alcohol sensitivity in other organisms. However, due to large variability in the experimental data and differences in sample sizes across conditions, the results should be considered preliminary, and future work will be aimed at increasing sample sizes and replication of results.en_US
dc.identifierhttps://doi.org/10.13016/h1gu-f2sc
dc.identifier.urihttp://hdl.handle.net/1903/28481
dc.language.isoenen_US
dc.subject.pqcontrolledNeurosciencesen_US
dc.subject.pquncontrolledacuteen_US
dc.subject.pquncontrolledalcoholen_US
dc.subject.pquncontrolledcrayfishen_US
dc.subject.pquncontrolledEtOHen_US
dc.subject.pquncontrolledserotoninen_US
dc.subject.pquncontrolledsocial isolationen_US
dc.titleINTERACTIONS BETWEEN SEROTONIN AND BEHAVIORAL SENSITIVITY TO ACUTE ALCOHOL EXPOSURE IN CRAYFISHen_US
dc.typeThesisen_US

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