Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate

Simple item page
dc.contributor.authorAnkra-Badu, Georgina A
dc.contributor.authorShriner, Daniel
dc.contributor.authorLe Bihan-Duval, Elisabeth
dc.contributor.authorMignon-Grasteau, Sandrine
dc.contributor.authorPitel, Frédérique
dc.contributor.authorBeaumont, Catherine
dc.contributor.authorDuclos, Michel J
dc.contributor.authorSimon, Jean
dc.contributor.authorPorter, Tom E
dc.contributor.authorVignal, Alain
dc.contributor.authorCogburn, Larry A
dc.contributor.authorAllison, David B
dc.contributor.authorYi, Nengjun
dc.contributor.authorAggrey, Samuel E
dc.date.accessioned2021-11-15T21:09:54Z
dc.date.available2021-11-15T21:09:54Z
dc.date.issued2010-02-11
dc.description.abstractDelineating the genetic basis of body composition is important to agriculture and medicine. In addition, the incorporation of gene-gene interactions in the statistical model provides further insight into the genetic factors that underlie body composition traits. We used Bayesian model selection to comprehensively map main, epistatic and sex-specific QTL in an F2 reciprocal intercross between two chicken lines divergently selected for high or low growth rate. We identified 17 QTL with main effects across 13 chromosomes and several sex-specific and sex-antagonistic QTL for breast meat yield, thigh + drumstick yield and abdominal fatness. Different sets of QTL were found for both breast muscles [Pectoralis (P) major and P. minor], which suggests that they could be controlled by different regulatory mechanisms. Significant interactions of QTL by sex allowed detection of sex-specific and sex-antagonistic QTL for body composition and abdominal fat. We found several female-specific P. major QTL and sex-antagonistic P. minor and abdominal fatness QTL. Also, several QTL on different chromosomes interact with each other to affect body composition and abdominal fatness. The detection of main effects, epistasis and sex-dimorphic QTL suggest complex genetic regulation of somatic growth. An understanding of such regulatory mechanisms is key to mapping specific genes that underlie QTL controlling somatic growth in an avian model.en_US
dc.description.urihttps://doi.org/10.1186/1471-2164-11-107
dc.identifierhttps://doi.org/10.13016/ulur-y5yd
dc.identifier.citationAnkra-Badu, G.A., Shriner, D., Le Bihan-Duval, E. et al. Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate. BMC Genomics 11, 107 (2010).en_US
dc.identifier.urihttp://hdl.handle.net/1903/28122
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtAnimal & Avian Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectQuantitative Trait Locusen_US
dc.subjectQuantitative Trait Locus Regionen_US
dc.subjectEffect Quantitative Trait Locusen_US
dc.subjectSignificant Quantitative Trait Locusen_US
dc.subjectCarcass Traiten_US
dc.titleMapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rateen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1471-2164-11-107.pdf
Size:
721.5 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.57 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Animal & Avian Sciences Research Works