miRNA-dysregulation associated with tenderness variation induced by acute stress in Angus cattle
miRNA-dysregulation associated with tenderness variation induced by acute stress in Angus cattle
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Date
2012-06-01
Authors
Zhao, Chunping
Tian, Fei
Yu, Ying
Liu, George
Zan, Linsen
Updike, M Scott
Song, Jiuzhou
Advisor
Citation
Zhao, C., Tian, F., Yu, Y. et al. miRNA-dysregulation associated with tenderness variation induced by acute stress in Angus cattle. J Animal Sci Biotechnol 3, 12 (2012).
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Abstract
miRNAs are a class of small, single-stranded, non-coding RNAs that perform post-transcriptional repression of target genes by binding to 3’ untranslated regions. Research has found that miRNAs involved in the regulation of many metabolic processes. Here we uncovered that the beef quality of Angus cattle sharply diversified after acute stress. By performing miRNA microarray analysis, 13 miRNAs were significantly differentially expressed in stressed group compared to control group. Using a bioinformatics method, 135 protein-coding genes were predicted as the targets of significant differentially expressed miRNAs. Gene Ontology (GO) term and Ingenuity Pathway Analysis (IPA) mined that these target genes involved in some important pathways, which may have impact on meat quality and beef tenderness.