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A Proposed Mechanical-Metabolic Model of the Human Red Blood Cell

dc.contributor.advisorSolares, Santiago Den_US
dc.contributor.authorOursler, Stephen Marken_US
dc.date.accessioned2014-06-26T05:44:08Z
dc.date.available2014-06-26T05:44:08Z
dc.date.issued2014en_US
dc.identifier.urihttp://hdl.handle.net/1903/15493
dc.description.abstractThe theoretical modeling and computational simulation of human red blood cells is of interest to researchers for both academic and practical reasons. The red blood cell is one of the simplest in the body, yet its complex behaviors are not fully understood. The ability to perform accurate simulations of the cell will assist efforts to treat disorders of the cell. In this thesis, a computational model of a human red blood cell that combines preexisting mechanical and metabolic models is proposed. The mechanical model is a coarse-grained molecular dynamics model, while the metabolic model considers the set of chemical reactions as a system of first-order ordinary differential equations. The models are coupled via the connectivity of the cytoskeleton with a novel method. A simulation environment is developed in MATLAB® to evaluate the combined model. The combined model and the simulation environment are described in detail and illustrated in this thesis.en_US
dc.language.isoenen_US
dc.titleA Proposed Mechanical-Metabolic Model of the Human Red Blood Cellen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentMechanical Engineeringen_US
dc.subject.pqcontrolledBiophysicsen_US
dc.subject.pqcontrolledCellular biologyen_US
dc.subject.pqcontrolledBiomedical engineeringen_US
dc.subject.pquncontrolledCell Metabolismen_US
dc.subject.pquncontrolledCoarse-Grainen_US
dc.subject.pquncontrolledMathematical Modelingen_US
dc.subject.pquncontrolledMolecular Dynamicsen_US
dc.subject.pquncontrolledReactive Dynamicsen_US
dc.subject.pquncontrolledSpring Network Percolationen_US


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