Self-determination has been identified as a major predictive factor for positive postsecondary outcomes for students with disabilities. The purpose of this study was to determine the role of self-determination in productive student engagement, perceived quality of life, and the ability to envision a career/life goal or future for students with multiple disabilities participating in a promising practices transition intervention. Results indicated significant results in the areas of student engagement and quality of life indicating the importance of self-determination on these factors. The results indicated a negative correlation between two of the self-determination subscales and envisioning a career/life goal which was an interesting and contradictory finding to the existing literature. Implications and recommendations are discussed.