A. James Clark School of Engineering
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The collections in this community comprise faculty research works, as well as graduate theses and dissertations.
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Item Thermal Isolation of High Power Devices in Heterogeneous Integration(2017) Fish, Michael Christopher; McCluskey, Patrick; Bar-Cohen, Avram; Mechanical Engineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Heterogeneous integration (HI) technologies present an important development in the pursuit of higher performance and reduced size, weight, power and cost of electronic systems (SWAP-C). HI systems, however, pose additional challenges for thermal management due to the disparate operating conditions of the devices. If the thermal coupling between devices can be reduced through a strategy of thermal isolation, then the SWAP-C of the accompanying thermal solution can also be reduced. This is in contrast to the alternative scenario of cooling the entire package to the maximum reliable temperature of the most sensitive devices. This isolation strategy must be implemented without a significant increase in device interconnect distances. A counter-intuitive approach is to seek packaging materials of low thermal conductivity – e.g. glass – and enhance them with arrays of metallic through-layer vias. This dissertation describes the first ever demonstration of integrating such via-enhanced interposers with microfluidic cooling, a thermal solution key to the high power applications for which HI was developed. Among the interposers tested, the best performing were shown to exhibit lower thermal coupling than bulk silicon in selective regions, validating their ability to provide thermal isolation. In the course of the study, the via-enhanced interposer is modeled as a thermal metamaterial with desirable, highly-anisotropic properties. Missing from the supporting literature is an accurate treatment of these interposers under such novel environments as microfluidic cooling. This dissertation identifies a new phenomenon, thermal microspreading, which governs how heat couples into a conductive via array from its surroundings. Both finite element analysis (FEA) and a new analytic solution of the associated boundary value problem (BVP) are used to develop a model for describing microspreading. This improves the ability to correctly predict the thermal behavior of via-enhanced interposers under diverse conditions.Item Design and Implementation of Microfluidic Systems for Bacterial Biofilm Monitoring and Manipulation(2014) Meyer, Mariana; Ghodssi, Reza; Bioengineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Bacterial biofilms - pathogenic matrices formed through bacterial communication and subsequent extracellular matrix secretion - characterize the majority of clinical bacterial infections. Biofilms exhibit increased resistance to conventional antibiotics, necessitating development of alternative treatments. Standard microbiological methods for studying biofilms often rely on in vitro systems with involved instrumentation for biofilm quantification, or destroy the biofilm in the process of characterization. Additionally, biofilm formation is sensitive to many growth parameters, and can exhibit a large degree of variability between repeated experiments. This dissertation presents the development of systems designed to address these challenges through integration of continuous biofilm monitoring in a microfluidic platform, and through creation of a microfluidic platform for multiple assays performed on one biofilm formed in a single channel. The microsystems developed in this work provide building blocks for developing controlled, high throughput testbeds for development and evaluation of drugs targeting bacterial biofilms. The first platform developed relied on optical density monitoring as a means for evaluating biofilm formation. This method was noninvasive, as it used an external light source and array of photodiodes to evaluate biofilms by the amount of light transmitted through the microfluidic channel where they were grown. The optical density biofilm measurement method and microfluidic platform were used to evaluate the dependence of biofilm formation on quorum sensing, an autoinducer-mediated intercellular communication process. This system was also used in the first demonstration of biofilm inhibition and reduction by two different autoinducer-2 analogs. The second microfluidic system developed addressed the challenge of variability in biofilm formation. Biofilms formed in a single microfluidic channel were partitioned by hydraulically actuated valves into three separate segments, which were then treated as representatives of the original biofilm in further experiments. A novel photoresist passivation process was developed in order to create the multi-depth channels needed to accommodate both valve actuation and biofilm formation. Biofilms grown in the device were uniform throughout, providing reliable experimental controls within the system. Biofilm partitioning was demonstrated by exposing three segments of one biofilm to varying detergent concentrations.Item A Microfluidic Programmable Array for Label-free Detection of Biomolecules(2011) Dykstra, Peter Hume; Ghodssi, Reza; Electrical Engineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)One of the most promising ways to improve clinical diagnostic tools is to use microfluidic Lab-on-a-chip devices. Such devices can provide a dense array of fluidic components and sensors at the micro-scale which drastically reduce the necessary sample volumes and testing time. This dissertation develops a unique electrochemical sensor array in a microfluidic device for high-throughput, label-free detection of both DNA hybridization and protein adsorption experiments. The device consists of a patterned 3 x 3 grid of electrodes which can be individually addressed and microfluidic channels molded using the elastomer PDMS. The channels are bonded over the patterned electrodes on a silicon or glass substrate. The electrodes are designed to provide a row-column addressing format to reduce the number of contact pads required and to drastically reduce the complexity involved in scaling the device to include larger arrays. The device includes straight channels of 100 micron height which can be manually rotated to provide either horizontal or vertical fluid flow over the patterned sensors. To enhance the design of the arrayed device, a series of microvalves were integrated with the platform. This integrated system requires rounded microfluidic channels of 32 micron height and a second layer of channels which act as pneumatic valves to pinch off selected areas of the microfluidic channel. With the valves, the fluid flow direction can be controlled autonomously without moving the bonded PDMS layer. Changes to the mechanism of detection and diffusion properties of the system were examined after the integration of the microvalve network. Protein adhesion studies of three different proteins to three functionalized surfaces were performed. The electrochemical characterization data could be used to help identify adhesion properties for surface coatings used in biomedical devices or for passivating sensor surfaces. DNA hybridization experiments were performed and confirmed both arrayed and sensitive detection. Hybridization experiments performed in the valved device demonstrated an altered diffusion regime which directly affected the detection mechanism. On average, successful hybridization yielded a signal increase 8x higher than two separate control experiments. The detection limit of the sensor was calculated to be 8 nM.