UMD Theses and Dissertations
Permanent URI for this collectionhttp://hdl.handle.net/1903/3
New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a given thesis/dissertation in DRUM.
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Item The Impact of Marsh Sill Living Shorelines on Coastal Resilience and Stability: Insights from Maryland's Chesapeake Bay and Coastal Bays(2024) Sun, Limin; Nardin, William WN; Palinkas, Cindy CP; Marine-Estuarine-Environmental Sciences; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Climate change and coastal urbanization are accelerating the demand for strategies to reduce shoreline erosion and enhance coastal resilience to storms and sea-level rise. Generally adverse ecological impacts of hardened infrastructure (e.g., seawalls, revetments, and dikes) have led to growing interest in alternative solutions. Living shorelines, increasingly recognized as sustainable Natural and Nature-Based Features (NNBFs; or Nature-Based Solutions (NBSs)) for their dual benefits of stabilizing shorelines while preserving or restoring coastal habitats, represent a promising approach to shoreline stabilization. Marsh sill living shorelines (created marshes with adjacent rock sills) have been extensively constructed in the Chesapeake Bay, notably in Maryland. Despite their popularity, significant uncertainties remain regarding their effectiveness and resiliency, especially during high-energy events. This dissertation investigates the dynamics of marsh sill living shorelines in Maryland’s Chesapeake Bay and Coastal Bays, aiming to fill knowledge gaps and inform effective shoreline stabilization strategies. First, the dissertation examines marsh boundary degradation into open water during high-energy conditions, contrasting mechanisms between living shorelines and natural marshes. Field surveys and numerical modeling reveal that while natural marshes experience erosion through undercutting and slumping at the scarp toe, living shorelines degrade primarily through open-water conversion at the marsh boundary behind rock sills. Differences in sediment characteristics and vegetation between the two ecosystems drive variations in marsh boundary stability between them. Next, the study assesses the impacts of rock sill placement on sediment dynamics and shoreline stability, highlighting the role of tidal gaps in enhancing sediment flux to the marsh and increasing vertical accretion during high-energy events. Numerical modeling demonstrates that while continuous sills mitigate erosion at the marsh edge of living shorelines, they diminish sediment deposition on the marsh platform compared to segmented sills with tidal gaps. Finally, the research identifies key factors driving marsh boundary degradation that are needed to assess the stability of marsh sill living shorelines. Analysis of eco-geomorphic features and hydrodynamics across 18 living shoreline sites reveals that metrics such as the Unvegetated/Vegetated Ratio (UVVR) and sediment deposition rate often used to assess the resilience of natural marshes also apply to the created marshes of living shorelines. Multivariate analyses further reveal that the Relative Exposure Index (REI) and Gap/Rock (G/R) ratio are crucial predictors of shoreline stability in marsh sill living shorelines, and thus should be particularly considered in shoreline design. By integrating remote sensing, field observations, and numerical modeling, this dissertation advances the understanding of sediment dynamics and stability in living shorelines and provides actionable insights for effective shoreline design and management to promote coastal resilience.Item UNDERSTANDING FUNCTIONAL BEHAVIORS OF ORGANOTROPIC TRIPLE NEGATIVE BREAST CANCER CELLS(2023) DeCastro, Ariana Joy; Stroka, Kimberly M; Bioengineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)11.7% of all cancer cases consist of breast cancer worldwide according to global cancer statistics. Triple negative breast cancer (TNBC) is subtype of breast cancer that has no expression of common hormonal receptors - estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Due to this, TNBC is insensitive to endocrine or molecular targeted therapy and chemotherapy is the most effective treatment. Additionally, TNBC patients have reoccurrence within 3 years of diagnosis. Going further, due to the non-specific targeting of chemotherapy, cancer cells can develop drug resistance. The gold standard does not work in conjunction with microenvironmental factors to reduce disease progression and drug resistance. Not only is this disease lacking in effective treatments but is associated with a health disparity being most prevalent in pre-menopausal and African American women. There is clearlya need to understand the mechanisms of TNBC metastasis because of the impact not only on women in general but on women in historically marginalized communities. A significant innovation in determining cancer treatment is the use of genomic sequencing to identify mutations associated with metastasis. However, tumor heterogeneity puts limitations on fully understanding genomic landscape of TNBC, a highly mutational disease, using sequencing. Further, even when mutations are identified they may not be targetable, or patients may not respond to treatments. While genomic sequencing can be beneficial in improving treatment outcomes, they require further downstream validation of genetic expression to completely understand tumor biology and metastatic progression. This is where understanding the functional behavior of tumor cells with respect to their preferred secondary microenvironment can be advantageous in supplementing genomics data to get a comprehensive understanding of TNBC metastasis. The overall goal of this dissertation is to address this gap by quantifying tumor cell functional behavior and their response to microenvironmental cues. We evaluate three different physical and biochemical behaviors of TNBC tumor cells. In Chapter 3, the effect of TNBC secretome on endothelial barrier properties and function is explored. Chapter 4 quantifies the morphological and migratory phenotypes of brain and bone-seeking TNBC cells in response to ECM protein substrates found in their relevant microenvironments. Lastly, Chapter 5 will quantify the TNBC incorporation in response to brain relevant microenvironmental cues. Quantifying these functional behaviors could provide indicators of brain and bone tropic metastatic behavior and have broader impacts in creating a complete physical profile of organotropic TNBC metastasis.Item SEX DIFFERENCES IN THE FOREBRAIN DOPAMINERGIC CIRCUIT(2022) Manion, Matthew Timothy Coon; Glasper, Erica R; Wang, Kuan Hong; Neuroscience and Cognitive Science; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Several psychiatric disorders exhibit different incidence rates in men and women and areassociated with dysfunctions in forebrain dopaminergic circuits. Although anatomical and functional sex differences in the brain have been studied, little is known about sex differences in the forebrain dopaminergic circuits associated with behavioral dysfunction. We hypothesized that known sex differences in forebrain dopamine circuit-associated behaviors would be the result of sex differences in forebrain dopamine circuit anatomy. As a first step to address this hypothesis, we combined a mouse transgenic driver line (tyrosine hydroxylase promoter-driven Cre recombinase) with virally encoded fluorescent reporters (FLEX-tdTomato and SynaptophysinGFP) to compare the density of midbrain dopaminergic axon projections and terminal boutons in dopamine projection target regions. Using this technique, we analyzed projections from the ventral tegmental area (VTA) to prefrontal cortex and basolateral amygdala (BLA) in male and female adult mice. Multiple analyses at 10x and 25x magnification revealed higher bouton density in BLA in males compared to females. To determine if this anatomical difference is mediated by gonadal steroid hormones, subjects were treated with a drug used to reduce gonadal steroid hormone production in clinical populations, leuprolide acetate (Lupron), before anatomical measures. Leuprolide administration resulted in a reduction in circulating testosterone, but did not show an effect on dopamine circuit anatomy. The finding of an anatomical sex difference in the forebrain dopamine circuit provides a structural foundation for further investigation of how sex differences in brain circuits may underlie behavioral dysfunction that play roles in psychiatric illnesses.Item Precedence and the Lack Thereof: Precedence-Relation-Oriented Phonology(2020) Papillon, Maxime; idsardi, Bill J.; Linguistics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)The study of representations, their limits and capacities, is an indispensable part of the formal study of language. The representations are the limits of what can be stored and computed upon, and the details of a representation have a major influence on the form of any analysis. Broadly, the goal of this thesis is to explore a lower bound of complexity for the phonological module. By exploring the capacities of a representation that I will argue requires fewer stipulations than anything offered before it, I will defend the claim that the freedom of this more powerful representation matches the power of morphology. More specifically I will argue that the representation of phonology is not strings, but directed graphs, and that this representation is simpler and more powerful and that its power exactly matches the set of attested phenomena of word-formation and phonology. The goal of this dissertation is to expand on the theory of Multiprecedence, which is both promising and under-explored.Item THE COMPARISON OF L1 AND L2 CASE PROCESSING: ERP EVIDENCE FROM TURKISH(2019) KARATAS, NUR BASAK; Gor, Kira; Second Language Acquisition and Application; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)This dissertation investigates the morphological and morphosyntactic processing of case-marking by native and nonnative speakers of Turkish, through behavioral and electrophysiological responses. The study explores the locus of case processing costs during first (L1) and second language (L2) word recognition both in isolation and in sentences. It identifies the factors leading to persistent problems that late L2 learners face in attaining native-like processing of case assignment. To this end, the first experiment (a visual lexical decision task) examines whether different case forms generate differential processing costs, based on four main comparisons that reflect case properties and its status in the inflectional paradigm: 1) structural (genitive, accusative) vs. lexical (dative) case; 2) argument (accusative, dative) vs. non-argument (genitive); 3) higher (genitive) vs. lower type frequency (accusative, dative), and 4) citation form (nominative) vs. oblique cases (genitive, accusative, dative). The behavioral findings show significantly larger processing costs (i.e., longer reaction times and lower accuracy rates) for the genitive than the nominative case (citation form) across both subject groups, and than other oblique cases in L2 group only. ERP findings show significantly larger processing costs for the genitive than the accusative, and for the dative than the accusative only in L2 group. When the same case-inflected nouns were placed in a sentence context, larger N400 effects were found for the genitive, compared to the nominative and accusative in L1 group only. Together, these results suggest that different case forms generate differential processing costs in both subject groups, and L2 learners’ difficulty with the non-argument genitive and lexical dative oblique cases are at the level of form rather than sentence structure. The second (sentence) experiment also examined the processing of case errors (i.e., substitution of the accusative for the dative or vice versa on the object). ERP findings show a qualitative difference between L1 and L2 morphosyntactic patterns: P600 was missing while early negativities (N400 and left anterior negativity, LAN) were present in L2 group. These results suggest that advanced L2 learners evaluate the verb argument structure (LAN) and semantic fit (N400), but do not attempt to reparse the sentence (P600), unlike native speakers.Item Development and the Early Animal Fossil Record: Evolution and Phylogenetic Applications(2016) Tweedt, Sarah Maureen; Delwiche, Charles F; Erwin, Douglas H; Cell Biology & Molecular Genetics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Although evolutionary developmental biology and paleontology are linked by the study of morphology, the application of development to paleontological questions has only recently become more prominent. The growth of a robust developmental genetic framework for studying the origin and evolution of morphological features, however, holds great promise for understanding ancient animal life. As paleontology provides the historical record as well as the temporal and environmental context of past morphological evolution, uniting knowledge of developmental genetic systems with this historical record will form a key synthetic approach to understanding the early evolution of developmental processes. Ultimately unraveling the sequence of ancient animal developmental evolution will require combining analysis of comparative developmental data, critical assessment of fossil morphology within a developmental framework, and the targeted exploration of specific geologic periods to fill in the missing record of key times in animal developmental evolution. This study addresses each of these three approaches. First, I provide a new compilation and evaluation of recent comparative and experimental developmental biology data to review the nature of developmental ‘toolkits’ at the origin of the most basal animal clades. I reconstruct early animal developmental capacities and integrate these data within a temporal framework to better understand the context of earliest animal development. Second, I assess longstanding evolutionary hypotheses about the origin of the panarthropod clade and the phylogenetic position of Cambrian ‘lobopod’ fossils by examining signal present within current morphological datasets. I apply new methods to fossil panarthropod phylogeny estimation and suggest strategies for developmentally-informed phylogenetic coding of morphological data. Third, I present the discovery of the oldest spicule-bearing fossil sponges in the rock record, which co-occur in latest Ediacaran strata with classic enigmatic Ediacaran fauna. I provide a formal systematic description of fossil material from localities in both Nevada and southern Namibia. The combined approaches presented herein are a first step towards a deeper integration of developmental principles in the study and discovery of ancient animal life, and contribute to our understanding of the evolution of ancient animal developmental processes.Item TAXONOMY, MORPHOLOGY, AND RNA-SEQ TRANSCRIPTOMICS OF THE CUBOZOAN ALATINA ALATA, AN EMERGING MODEL CNIDARIAN(2016) Ames, Cheryl L; Bely, Alexandra E; Collins, Allen G; Behavior, Ecology, Evolution and Systematics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Cnidarians are often considered simple animals, but the more than 13,000 estimated species (e.g., corals, hydroids and jellyfish) of the early diverging phylum exhibit a broad diversity of forms, functions and behaviors, some of which are demonstrably complex. In particular, cubozoans (box jellyfish) are cnidarians that have evolved a number of distinguishing features. Some cubozoan species possess complex mating behaviors or particularly potent stings, and all possess well-developed light sensation involving image-forming eyes. Like all cnidarians, cubozoans have specialized subcellular structures called nematocysts that are used in prey capture and defense. The objective of this study is to contribute to the development of the box jellyfish Alatina alata as a model cnidarian. This cubozoan species offers numerous advantages for investigating morphological and molecular traits underlying complex processes and coordinated behavior in free-living medusozoans (i.e., jellyfish), and more broadly throughout Metazoa. First, I provide an overview of Cnidaria with an emphasis on the current understanding of genes and proteins implicated in complex biological processes in a few select cnidarians. Second, to further develop resources for A. alata, I provide a formal redescription of this cubozoan and establish a neotype specimen voucher, which serve to stabilize the taxonomy of the species. Third, I generate the first functionally annotated transcriptome of adult and larval A. alata tissue and apply preliminary differential expression analyses to identify candidate genes implicated broadly in biological processes related to prey capture and defense, vision and the phototransduction pathway and sexual reproduction and gametogenesis. Fourth, to better understand venom diversity and mechanisms controlling venom synthesis in A. alata, I use bioinformatics to investigate gene candidates with dual roles in venom and digestion, and review the biology of prey capture and digestion in cubozoans. The morphological and molecular resources presented herein contribute to understanding the evolution of cubozoan characteristics and serve to facilitate further research on this emerging cubozoan model.Item The neuro-humoral control of circulation, or the morphology and physiology of the vascular changes involved in gill reduction in salamanders(1934) Figge, Frank H. J.; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)Item An anatomical and chemical study of inbred and crossbred strains of guinea pigs(1935) Eaton, Orson Northrup; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)Item The skeletal musculature of the blue crab, Callinectes sapidus Rathbun(1933) Cochran, Doris M.; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)
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