Biomechanical and functional variation in rat sciatic nerve following cuff electrode implantation

dc.contributor.authorRestaino, Stephen M
dc.contributor.authorAbliz, Erkinay
dc.contributor.authorWachrathit, Kelliann
dc.contributor.authorKrauthamer, Victor
dc.contributor.authorShah, Sameer B
dc.date.accessioned2021-09-21T14:27:45Z
dc.date.available2021-09-21T14:27:45Z
dc.date.issued2014-04-23
dc.description.abstractNerve cuff electrodes are commonly and successfully used for stimulating peripheral nerves. On the other hand, they occasionally induce functional and morphological changes following chronic implantation, for reasons not always clear. We hypothesize that restriction of nerve mobility due to cuff implantation may alter nerve conduction. We quantified acute changes in nerve-muscle electrophysiology, using electromyography, and nerve kinematics in anesthetized Sprague Dawley rat sciatic nerves during controlled hindlimb joint movement. We compared electrophysiological and biomechanical response in uncuffed nerves and those secured within a cuff electrode using analysis of variance (ANOVA) and regression analysis. Tethering resulting from cuff implantation resulted in altered nerve strain and a complex biomechanical environment during joint movement. Coincident with biomechanical changes, electromyography revealed significantly increased variability in the response of conduction latency and amplitude in cuffed, but not free, nerves following joint movement. Our findings emphasize the importance of the mechanical interface between peripheral nerves and their devices on neurophysiological performance. This work has implications for nerve device design, implantation, and prediction of long-term efficacy.en_US
dc.description.urihttps://doi.org/10.1186/1743-0003-11-73
dc.identifierhttps://doi.org/10.13016/mrhl-jsdl
dc.identifier.citationRestaino, S.M., Abliz, E., Wachrathit, K. et al. Biomechanical and functional variation in rat sciatic nerve following cuff electrode implantation. J NeuroEngineering Rehabil 11, 73 (2014).en_US
dc.identifier.urihttp://hdl.handle.net/1903/27893
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtA. James Clark School of Engineeringen_us
dc.relation.isAvailableAtFischell Department of Bioengineeringen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectPeripheral nerveen_US
dc.subjectCuffen_US
dc.subjectElectrodeen_US
dc.subjectElectrophysiologyen_US
dc.subjectBiomechanicsen_US
dc.subjectElectromyographyen_US
dc.subjectEMGen_US
dc.titleBiomechanical and functional variation in rat sciatic nerve following cuff electrode implantationen_US
dc.typeArticleen_US

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