The MEIOTIC PROPHASE AMINOPEPTIDASE 1 regulates polyploidy in Arabidopsis thaliana

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dc.contributor.advisorPeer, Wendy Aen_US
dc.contributor.authorWattarantenne, Kasuni Vishwaprabhaen_US
dc.contributor.departmentPlant Science and Landscape Architecture (PSLA)en_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2018-01-25T06:35:59Z
dc.date.available2018-01-25T06:35:59Z
dc.date.issued2017en_US
dc.description.abstractGrowth and development in plants is dependent on cellular functions such as cell cycle progression. M1 aminopeptidases have been shown to regulate mitosis and meiosis in animals. MEIOTIC PROPHASE AMINOPEPTIDASE M1 (MPA1) in Arabidopsis thaliana was previously shown to regulate cell cycle progression during prophase I in meiosis I in both female and male gametophytes and be essential for homologous recombination. mpa1 homozygous embryos are lethal due to chromosome de-synapsis resulting in uneven distribution of chromosomes in daughter cells and massive decrease in homologous crossovers reduces independent assortment. Here, I show that MPA1 is a soluble protein and is expressed throughout the seedling: in the primary root, hypocotyl, cotyledons, petioles and root and shoot apical meristem. I isolated and characterized four mpa1 alleles, and I showed that MPA1 loss-of-function mutants exhibited three significant phenotypes corresponding to development in seedlings and adult plants in Arabidopsis: non-disjunction in mitotic cells, altered polyploidy, and temporary arrest of primary root growth during seedling establishment.en_US
dc.identifierhttps://doi.org/10.13016/M27P8TF8C
dc.identifier.urihttp://hdl.handle.net/1903/20446
dc.language.isoenen_US
dc.subject.pqcontrolledPlant sciencesen_US
dc.subject.pqcontrolledGeneticsen_US
dc.subject.pqcontrolledBiologyen_US
dc.subject.pquncontrolledArabidopsisen_US
dc.subject.pquncontrolledchromosome nondisjunctionen_US
dc.subject.pquncontrolledMEIOTIC PROPHASE AMINOPEPTIDASE 1en_US
dc.subject.pquncontrolledpolyploidyen_US
dc.titleThe MEIOTIC PROPHASE AMINOPEPTIDASE 1 regulates polyploidy in Arabidopsis thalianaen_US
dc.typeThesisen_US

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