Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance?

dc.contributor.authorRocourt, Caroline R. B.
dc.contributor.authorCheng, Wen-Hsing
dc.date.accessioned2024-01-30T17:00:12Z
dc.date.available2024-01-30T17:00:12Z
dc.date.issued2013-04-19
dc.description.abstractSelenium was considered a toxin until 1957, when this mineral was shown to be essential in the prevention of necrotic liver damage in rats. The hypothesis of selenium chemoprevention is principally formulated by the observations that cancer incidence is inversely associated with selenium status. However, recent clinical and epidemiological studies demonstrate a role for some selenoproteins in exacerbating or promoting other disease states, specifically type 2 diabetes, although other data support a role of selenium in stimulating insulin sensitivity. Therefore, it is clear that our understanding in the role of selenium in glucose metabolism and chemoprevention is inadequate and incomplete. Research exploring the role of selenium in individual healthcare is of upmost importance and possibly will help explain how selenium is a double-edged sword in the pathologies of chronic diseases.
dc.description.urihttps://doi.org/10.3390/nu5041349
dc.identifierhttps://doi.org/10.13016/dspace/zbvo-wcye
dc.identifier.citationRocourt, C.R.B.; Cheng, W.-H. Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance? Nutrients 2013, 5, 1349-1365.
dc.identifier.urihttp://hdl.handle.net/1903/31612
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtNutrition & Food Scienceen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectselenium
dc.subjectsupranutrition
dc.subjecttype 2 diabetes
dc.subjectcancer
dc.titleSelenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance?
dc.typeArticle
local.equitableAccessSubmissionNo

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