Pharmaceutical Innovation through Laser Lithography Strategies

Abstract

The Human Immunodeficiency Virus is an autoimmune disease which targets the body’s immune system, leaving individuals at risk of worse infections, such as AIDS. Currently, HIV is treated via drug cocktails limited by synthesized particle size, architecture, material composition, and lack of controlled drug release. Advancements in additive manufacturing through the use of Direct Laser Writing (DLW) and biodegradable structures have allowed for new methods of drug cocktail delivery. This project utilizes additive manufacturing to develop a biodegradable capsule with geometry that can be easily modified to control the release of the HIV drug cocktails. A mixture of PEGDA 250 and PETA was optimal for fabricating microcapsules, a teardrop design was tested for shell performance, and microchips facilitate targeting liquid to the shell. Our research shows promise towards the delivery of medications via controlled release mechanisms by allowing for continuous administration of medication to maintain the therapeutic window.