Synbiotic-like effect of linoleic acid overproducing Lactobacillus casei with berry phenolic extracts against pathogenesis of enterohemorrhagic Escherichia coli

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dc.contributor.authorTabashsum, Zajeba
dc.contributor.authorPeng, Mengfei
dc.contributor.authorBernhardt, Cassendra
dc.contributor.authorPatel, Puja
dc.contributor.authorCarrion, Michael
dc.contributor.authorBiswas, Debabrata
dc.date.accessioned2021-06-07T17:11:39Z
dc.date.available2021-06-07T17:11:39Z
dc.date.issued2019-07-27
dc.description.abstractMajority of enteric infections are foodborne and antimicrobials including antibiotics have been used for their control and treatment. However, probiotics or prebiotics or their combination offer a potential alternative intervention strategy for improving the host health and preventing foodborne pathogen colonization/infections in reservoir. Further, bioengineered probiotics expressing bioactive products to achieve specific function is highly desirable. Recently, we over-expressed mcra (myosin cross-reactive antigen) gene in Lactobacillus casei (Lc) and developed a bioengineered probiotics Lc + CLA which produce higher amounts of metabolites including conjugated linoleic acid (CLA). Furthermore, we also reported that prebiotic like components such as berry pomace (byproduct) phenolic extracts (BPEs) can enhance the growth of probiotics and improved the beneficial effects of probiotics. In this study, we evaluated the antimicrobial effect of modified Lc + CLA in combination of BPEs on growth, survival and pathogenesis of enterohemorrhagic Escherichia coli (EHEC).en_US
dc.description.urihttps://doi.org/10.1186/s13099-019-0320-y
dc.identifierhttps://doi.org/10.13016/gjo1-yn2n
dc.identifier.citationTabashsum, Z., Peng, M., Bernhardt, C. et al. Synbiotic-like effect of linoleic acid overproducing Lactobacillus casei with berry phenolic extracts against pathogenesis of enterohemorrhagic Escherichia coli. Gut Pathog 11, 41 (2019).en_US
dc.identifier.urihttp://hdl.handle.net/1903/27121
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtAnimal & Avian Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectEHECen_US
dc.subjectPrebioticen_US
dc.subjectProbioticen_US
dc.subjectSynbioticen_US
dc.subjectPreventionen_US
dc.titleSynbiotic-like effect of linoleic acid overproducing Lactobacillus casei with berry phenolic extracts against pathogenesis of enterohemorrhagic Escherichia colien_US
dc.typeArticleen_US

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