Fabrication and Packaging Optimization for Polymer-Based Microfluidics

dc.contributor.advisorRubloff, Gary Wen_US
dc.contributor.authorValentine, Theresa Michelleen_US
dc.contributor.departmentMaterial Science and Engineeringen_US
dc.date.accessioned2004-06-04T05:35:30Z
dc.date.available2004-06-04T05:35:30Z
dc.date.issued2004-04-30en_US
dc.description.abstractPackaging microelectromechanical systems (MEMS) often accounts for 80 percent of both the cost and the failures of the devices. For biological MEMS with microfluidic channels, packaging requires reliable fluid and electrical connections. This work describes various strategies for optimizing the fabrication of microfluidic circuits and the design of leak-tight, re-usable, multi-functional packaging systems. Various materials are surveyed to determine the appropriate microfluidic chip substrate for an all-polymer device. Three unique test site designs allow combinatorial experiments and improve the functionality of three proven leak-tight packaging fixtures. Finally, the successful deposition of chitosan, a polysaccharide biopolymer that can act as the interface layer between inorganic electrodes and biological components such as proteins and nucleic acids, is shown in a packaged microfluidic environment for the first time. This study lays the groundwork for future applications in miniaturized bio-reactors and chemical and biological sensors.en_US
dc.format.extent4572797 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/1412
dc.language.isoen_US
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_US
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md.)en_US
dc.subject.pqcontrolledEngineering, Materials Scienceen_US
dc.titleFabrication and Packaging Optimization for Polymer-Based Microfluidicsen_US
dc.typeThesisen_US

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