Differential requirements of the hindbrain and mesenchyme on inner ear patterning

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dc.contributor.advisorLee, Hey-Kyoungen_US
dc.contributor.advisorWu, Doris Ken_US
dc.contributor.authorLiang, Jennifer Kimikoen_US
dc.contributor.departmentBiologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2009-07-02T05:33:52Z
dc.date.available2009-07-02T05:33:52Z
dc.date.issued2009en_US
dc.description.abstractMicrosurgical manipulations were performed in ovo to identify the tissues that are required for conferring inner ear patterning. Our results show that the hindbrain, namely rhombomeres 5 and 6, are required for the formation and patterning of the cochlear duct (basilar papilla). Rhombomere 5 and its underlying notochord appear to be important for the growth of the cochlear duct, whereas rhomobomere 6 and its respective notochord are required for cochlear patterning. Rotating the segment of hindbrain from rhombomere 5 to rhombomere 6 along the anteroposterior axis affects cochlear duct formation but has no effect on the development of vestibular structures. The signaling molecules intrinsic to these tissues are distinct from Sonic Hedgehog, which has been shown to be required for cochlear duct outgrowth. In contrast, otic mesenchyme adjacent to the developing inner ear provides anteroposterior axial information to pattern the anterior and posterior canals and ampullae.en_US
dc.format.extent33068229 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/9114
dc.language.isoen_US
dc.subject.pqcontrolledBiology, Molecularen_US
dc.subject.pqcontrolledBiology, Neuroscienceen_US
dc.subject.pqcontrolledBiology, Cellen_US
dc.subject.pquncontrolledaxial specificationen_US
dc.subject.pquncontrolledchickenen_US
dc.subject.pquncontrolledhindbrainen_US
dc.subject.pquncontrolledInner ear patterningen_US
dc.subject.pquncontrolledmesenchymeen_US
dc.subject.pquncontrolledrhombomereen_US
dc.titleDifferential requirements of the hindbrain and mesenchyme on inner ear patterningen_US
dc.typeThesisen_US

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