DEVELOPMENT AND IN-SILICO EVALUATION OF A CLOSED-LOOP FLUID RESUSCITATION CONTROL ALGORITHM WITH MEAN ARTERIAL PRESSURE FEEDBACK

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dc.contributor.advisorHahn, Jin-Ohen_US
dc.contributor.authorAlsalti, Mohammaden_US
dc.contributor.departmentMechanical Engineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2020-10-10T05:31:16Z
dc.date.available2020-10-10T05:31:16Z
dc.date.issued2020en_US
dc.description.abstractIn this thesis, a model-based closed-loop fluid resuscitation controller using mean arterial pressure (MAP) feedback is designed and later evaluated on an in-silico testbed. The controller is based on a subject specific model of blood volume and MAP response to fluid infusion. This simple hemodynamic model is described using five parameters only. The model was able to reproduce blood volume and blood pressure response to fluid infusion using an experimental dataset collected from 23 sheep and is therefore suitable to use for control design purposes. A model-reference adaptive control scheme was chosen to account for inter-subject variability captured in the parametric uncertainties of the underlying physiological model. Three versions of the control algorithm were studied under different measurement availability scenarios. In-silico evaluation of the three controllers was done using a comprehensive cardiovascular physiology model on a cohort of 100 virtually generated patients. Results clearly show that a tradeoff exists between tracking and estimation performance depending on measurement availability.en_US
dc.identifierhttps://doi.org/10.13016/stfh-b4bq
dc.identifier.urihttp://hdl.handle.net/1903/26575
dc.language.isoenen_US
dc.subject.pqcontrolledMechanical engineeringen_US
dc.subject.pquncontrolledAdaptive controlen_US
dc.subject.pquncontrolledBlood pressureen_US
dc.subject.pquncontrolledClosed-loop controlen_US
dc.subject.pquncontrolledComposite adaptive controlen_US
dc.subject.pquncontrolledFluid resuscitationen_US
dc.subject.pquncontrolledModel reference adaptive controlen_US
dc.titleDEVELOPMENT AND IN-SILICO EVALUATION OF A CLOSED-LOOP FLUID RESUSCITATION CONTROL ALGORITHM WITH MEAN ARTERIAL PRESSURE FEEDBACKen_US
dc.typeThesisen_US

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