The influence of ECE-1 gene polymorphism and exercise training on plasma and urinary endothelin-1 levels in pre- and stage 1 hypertensives

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dc.contributor.advisorHagberg, Jamesen_US
dc.contributor.authorAttipoe, Selasien_US
dc.contributor.departmentKinesiologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2007-09-28T15:02:23Z
dc.date.available2007-09-28T15:02:23Z
dc.date.issued2007-08-09en_US
dc.description.abstractEndothelin-1 (ET-1) is a peptide that mediates blood pressure. ECE-1b-C-338A is a polymorphism in the ECE-1 gene that alters ET-1 synthesis. Thus, the goal of this study was to investigate the influence of the ECE-1b-C-338A polymorphism on plasma and urinary ET-1 levels, as well as on aerobic exercise training (AEX)-induced changes in these variables. Outcome variables were assessed before and after 24 weeks of AEX in hypertensive adults. Separate ANCOVAs were used to compare differences in outcome variables. Only AA homozygote men had higher plasma ET-1 levels. After AEX, there were no significant changes in the main outcome variables. Neither were these changes significantly different between genotype groups. Results suggest that this polymorphism is associated with plasma ET-1 levels in men but not with urinary ET-1 levels. Additionally, this polymorphism does not affect AEX-induced changes in plasma and urinary ET-1 levels.en_US
dc.format.extent751044 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/7371
dc.language.isoen_US
dc.subject.pqcontrolledBiology, Physiologyen_US
dc.subject.pqcontrolledGerontologyen_US
dc.subject.pqcontrolledHealth Sciences, Public Healthen_US
dc.subject.pquncontrolledendothelin-1en_US
dc.subject.pquncontrolledendothelin converting enzymeen_US
dc.subject.pquncontrolledblood pressureen_US
dc.subject.pquncontrolledexercise trainingen_US
dc.titleThe influence of ECE-1 gene polymorphism and exercise training on plasma and urinary endothelin-1 levels in pre- and stage 1 hypertensivesen_US
dc.typeThesisen_US

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