DNA Methylation and Regulatory Elements during Chicken Germline Stem Cell Differentiation

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dc.contributor.authorHe, Yanghua
dc.contributor.authorZuo, Qisheng
dc.contributor.authorEdwards, John
dc.contributor.authorZhao, Keji
dc.contributor.authorLei, Jinzhi
dc.contributor.authorCai, Wentao
dc.contributor.authorNie, Qing
dc.contributor.authorLi, Bichun
dc.contributor.authorSong, Jiuzhou
dc.date.accessioned2018-06-29T17:02:01Z
dc.date.available2018-06-29T17:02:01Z
dc.date.issued2018-06-05
dc.descriptionFunding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.en_US
dc.description.abstractThe production of germ cells in vitro would open important new avenues for stem biology and human medicine, but the mechanisms of germ cell differentiation are not well understood. The chicken, as a great model for embryology and development, was used in this study to help us explore its regulatory mechanisms. In this study, we reported a comprehensive genome-wide DNA methylation landscape in chicken germ cells, and transcriptomic dynamics was also presented. By uncovering DNA methylation patterns on individual genes, some genes accurately modulated by DNA methylation were found to be associated with cancers and virus infection, e.g., AKT1 and CTNNB1. Chicken-unique markers were also discovered for identifying male germ cells. Importantly, integrated epigenetic mechanisms were explored during male germ cell differentiation, which provides deep insight into the epigenetic processes associated with male germ cell differentiation and possibly improves treatment options to male infertility in animals and humans.en_US
dc.identifierhttps://doi.org/10.13016/M2VM4312S
dc.identifier.citationStem Cell Reports, Volume 10, Issue 6, 5 June 2018, Pages 1793-1806; https://doi.org/10.1016/j.stemcr.2018.03.018en_US
dc.identifier.urihttp://hdl.handle.net/1903/20706
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtAnimal & Avian Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.titleDNA Methylation and Regulatory Elements during Chicken Germline Stem Cell Differentiationen_US
dc.typeArticleen_US

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