TARGETING MAGNETIC NANOCARRIERS IN THE HEAD FOR DRUG DELIVERY AND BIOSENSING APPLICATIONS

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dc.contributor.advisorShapiro, Benjaminen_US
dc.contributor.authorRamaswamy, Bharathen_US
dc.contributor.departmentBioengineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2017-06-22T05:40:16Z
dc.date.available2017-06-22T05:40:16Z
dc.date.issued2016en_US
dc.description.abstractMagnetic nanocarriers have proven to be effective vehicles for transporting therapeutic and diagnostic agents in the body. Their main advantage is their ability to be manipulated by external magnets to direct them to specific targets in the body. In this dissertation, I study the transport, safety and efficacy of moving drug coated magnetic nanocarriers in different types of tissue. Movement of magnetic nanocarriers of sizes ranging from 100 nm to 1µm with different biocompatible coatings (Starch, PEG, Lipid and Chitosan) was quantified in different tissue types using an automated cryostat system. The safety of moving magnetic nanocarriers in live rodent brain tissue was assessed using electrophysiology, calcium imaging and immunohistochemistry. Moving magnetic nanocarriers in brain tissue did not significantly affect the firing ability of single neurons, synaptic connectivity and the overall functioning of the neuron network. As part of efficacy studies, steroid-eluting magnetic nanoparticles were targeted using external magnets to the inner ear of mice to counter hearing loss caused by cisplatin chemotherapeutics. This targeted steroid delivery to the cochlea significantly reduced the change in hearing threshold at 32 KHz caused by cisplatin injections and protected the hair cells from significant damage. Finally, I explore the potential of spin-transfer torque nano-oscillators, which are multi-layered ferromagnetic nanocarriers, as high-resolution in vivo wireless biosensors. These nanocarriers have been shown to detect action potentials from crayfish lateral giant neurons and that the microwave magnetic signals from these devices can be detected wirelessly by near field induction.en_US
dc.identifierhttps://doi.org/10.13016/M2X57D
dc.identifier.urihttp://hdl.handle.net/1903/19299
dc.language.isoenen_US
dc.subject.pqcontrolledBiomedical engineeringen_US
dc.subject.pqcontrolledNanotechnologyen_US
dc.subject.pqcontrolledMedicineen_US
dc.subject.pquncontrolledMagnetic nanocarriersen_US
dc.subject.pquncontrolledNeuroimagingen_US
dc.subject.pquncontrolledOtotoxicityen_US
dc.subject.pquncontrolledSafetyen_US
dc.subject.pquncontrolledSpin transfer nano-oscillatorsen_US
dc.subject.pquncontrolledTargetingen_US
dc.titleTARGETING MAGNETIC NANOCARRIERS IN THE HEAD FOR DRUG DELIVERY AND BIOSENSING APPLICATIONSen_US
dc.typeDissertationen_US

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