EFFECT OF ANTHOCYANIN-RICH EXTRACTS ON 5-FLUROURACIL CHEMOTHERAPY

dc.contributor.advisorMagnuson, Bernadeneen_US
dc.contributor.authorsu, yeen_US
dc.contributor.departmentFood Scienceen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2006-02-04T08:25:00Z
dc.date.available2006-02-04T08:25:00Z
dc.date.issued2006-01-24en_US
dc.description.abstractAnthocyanins are natural colorants, with potential chemopreventive activity. 5-Flurouracil (5-Fu) is a widely used cancer chemotherapeutic drug. However, it has serious side effects. Objective: To determine whether anthocyanin-rich-extracts (ARE) can increase the effectiveness of 5-Fu. Methods: Colon cancer cells were treated with ARE in combination with 5-Fu to assess in vitro whether ARE would enhance 5-Fu cytotoxicity. In vivo, rats were given diets with or without ARE for 14 days. On day 11, rats were injected with either 5-Fu or its vehicle. Total blood cells counts and pathological analyses were conducted. Results: ARE enhanced the growth inhibition by 5-Fu in colon cancer cell lines, but almost had no effect on normal colon cells. 5-Fu had serious side effects on the rats. Dietary ARE partially reduced the gastrointestinal damage by 5-Fu. Further studies with advanced tumor models are needed to assess effect of ARE on 5-Fu tumor inhibition in vivo.en_US
dc.format.extent8288709 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/3320
dc.language.isoen_US
dc.subject.pqcontrolledAgriculture, Food Science and Technologyen_US
dc.titleEFFECT OF ANTHOCYANIN-RICH EXTRACTS ON 5-FLUROURACIL CHEMOTHERAPYen_US
dc.typeThesisen_US
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