Characterization of Copy Number Variation’s Potential Role in Marek’s Disease

Simple item page
dc.contributor.authorXu, Lingyang
dc.contributor.authorHe, Yanghua
dc.contributor.authorDing, Yi
dc.contributor.authorSun, Guirong
dc.contributor.authorCarrillo, Jose Adrian
dc.contributor.authorLi, Yaokun
dc.contributor.authorGhaly, Mona M.
dc.contributor.authorMa, Li
dc.contributor.authorZhang, Huanmin
dc.contributor.authorLiu, George E.
dc.contributor.authorSong, Jiuzhou
dc.date.accessioned2023-11-28T17:46:08Z
dc.date.available2023-11-28T17:46:08Z
dc.date.issued2017-05-09
dc.description.abstractMarek’s Disease (MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. Chicken Lines 63 and 72, as well as their recombinant congenic strains (RCS) with varied susceptibility to MD, are ideal models to study the complex mechanisms of genetic resistance to MD. In this study, we investigated copy number variation (CNV) in these inbred chicken lines using the Affymetrix Axiom HD 600 K SNP genotyping array. We detected 393 CNV segments across all ten chicken lines, of which 12 CNVs were specifically identified in Line 72. We then assessed genetic structure based on CNV and observed markedly different patterns. Finally, we validated two deletion events in Line 72 and correlated them with genes expression using qPCR and RNA-seq, respectively. Our combined results indicated that these two CNV deletions were likely to contribute to MD susceptibility.
dc.description.urihttps://doi.org/10.3390/ijms18051020
dc.identifierhttps://doi.org/10.13016/dspace/l9y3-gw9i
dc.identifier.citationXu, L.; He, Y.; Ding, Y.; Sun, G.; Carrillo, J.A.; Li, Y.; Ghaly, M.M.; Ma, L.; Zhang, H.; Liu, G.E.; et al. Characterization of Copy Number Variation’s Potential Role in Marek’s Disease. Int. J. Mol. Sci. 2017, 18, 1020.
dc.identifier.urihttp://hdl.handle.net/1903/31509
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtAnimal & Avian Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectcopy number variation
dc.subjectchicken
dc.subjectinbred lines
dc.subjectrecombinant congenic strains (RCS)
dc.subjectMarek's disease
dc.subjectRNA-sequencing
dc.titleCharacterization of Copy Number Variation’s Potential Role in Marek’s Disease
dc.typeArticle
local.equitableAccessSubmissionNo

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijms-18-01020.pdf
Size:
3.84 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.55 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Animal & Avian Sciences Research Works