The Application of an Exogenous Linear and Radial Electrical Field to an In Vitro Chronic Diabetic Ulcer Model for Evaluation as a Potential Treatment

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dc.contributor.advisorFisher, John
dc.contributor.authorAhmed, Sagah
dc.contributor.authorAnzures, Natalie
dc.contributor.authorBosley, Zachary
dc.contributor.authorBui, Brendan
dc.contributor.authorFeizi, Ariana
dc.contributor.authorJawahery, Sudi
dc.contributor.authorKoenig, Courtney
dc.contributor.authorLakomy, Katherine
dc.contributor.authorLin, Megan
dc.contributor.authorNatarajan, Poorna
dc.contributor.authorNathan, Eisha
dc.contributor.authorSayed, Hiba
dc.contributor.authorSolano, Eduardo
dc.date.accessioned2014-07-16T13:38:24Z
dc.date.available2014-07-16T13:38:24Z
dc.date.issued2014
dc.description.abstractChronic diabetic ulcers affect approximately 15% of patients with diabetes worldwide. Currently, applied electric fields are being investigated as a reliable and cost-effective treatment. This in vitro study aimed to determine the effects of a constant and spatially variable electric field on three factors: endothelial cell migration, proliferation, and angiogenic gene expression. Results for a constant electric field of 0.01 V demonstrated that migration at short time points increased 20-fold and proliferation at long time points increased by a factor of 1.40. Results for a spatially variable electric field did not increase directional migration, but increased proliferation by a factor of 1.39 and by a factor of 1.55 after application of 1.00 V and 0.01 V, respectively. Both constant and spatially variable applied fields increased angiogenic gene expression. Future research that explores a narrower range of intensity levels may more clearly identify the optimal design specifications of a spatially variable electric field.en_US
dc.identifier.urihttp://hdl.handle.net/1903/15531
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectDiabetesen_US
dc.subjectUlcersen_US
dc.subjectElectric fieldsen_US
dc.subjectGemstone Team ELECTRODEen_US
dc.titleThe Application of an Exogenous Linear and Radial Electrical Field to an In Vitro Chronic Diabetic Ulcer Model for Evaluation as a Potential Treatmenten_US
dc.typeThesisen_US

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