SEX-SPECIFIC EFFECTS OF PATERNAL DEPRIVATION ON HYPOTHALAMIC NEUROIMMUNE RESPONSE AND GENERAL ANXIETY-LIKE BEHAVIOR IN PEROMYSCUS CALIFORNICUS (CALIFORNIA MICE)

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dc.contributor.advisorGlasper, Erica Ren_US
dc.contributor.authorWalker, Shakeeraen_US
dc.contributor.departmentNeuroscience and Cognitive Scienceen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2022-02-04T06:30:13Z
dc.date.available2022-02-04T06:30:13Z
dc.date.issued2021en_US
dc.description.abstractEarly-life stress (ELS) can induce anxiety-like behaviors and social deficits in male and female rodent models via neuroinflammation. The California mouse (Peromyscus californicus) is a rodent model for paternal deprivation (PD), a form of ELS. The paternal California mouse is essential in offspring development; his absence impairs emotional regulation and induces sex-specific deficits in social behaviors and neuroplasticity. We determined to what extent PD induced sex-specific social and anxiety-like behaviors in adult California mice during the three-chamber social interaction test and the novelty-suppressed feeding test. We also assessed the neuroinflammatory response to PD in the same mice after an acute physical stressor. We demonstrated that female California mice displayed social avoidance, while PD males exhibited stress-induced eating in novel anxiogenic environments. PD also increased hypothalamic interleukin-1β, but only in adult males. Taken together, PD resulted in sex-dependent stress-coping behaviors, which may underlie sex differences in neuroinflammatory responses in adulthood.en_US
dc.identifierhttps://doi.org/10.13016/wjxb-2efp
dc.identifier.urihttp://hdl.handle.net/1903/28393
dc.language.isoenen_US
dc.subject.pqcontrolledNeurosciencesen_US
dc.subject.pqcontrolledBehavioral sciencesen_US
dc.subject.pqcontrolledImmunologyen_US
dc.titleSEX-SPECIFIC EFFECTS OF PATERNAL DEPRIVATION ON HYPOTHALAMIC NEUROIMMUNE RESPONSE AND GENERAL ANXIETY-LIKE BEHAVIOR IN PEROMYSCUS CALIFORNICUS (CALIFORNIA MICE)en_US
dc.typeThesisen_US

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