Characterization of Iron Oxide Nanoparticles in Structural Silk-elastinlike Protein Polymer

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dc.contributor.advisorBriber, Robert Men_US
dc.contributor.authorShih, Jenniferen_US
dc.contributor.departmentMaterial Science and Engineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2012-07-07T05:58:18Z
dc.date.available2012-07-07T05:58:18Z
dc.date.issued2012en_US
dc.description.abstractThe structure of silk elastin-like protein (SELP) block copolymers containing Fe3O4 magnetic nanoparticles are investigated. These materials have potential applications for hyperthermia cancer therapy. SELPs undergo a gel transition at physiological temperatures, which can be used to localize delivery of nanoparticles at tumor sites. Vibrating sample magnetometry (VSM), transmission electron microscopy (TEM), and small angle neutron scattering (SANS) are used to characterize the nanoparticles and the SELP-nanoparticle nanocomposite system. A series of nanoparticles with three different nominal diameters, 30, 50 and 80 nm, were added to 4 and 8 wt.% SELP samples. Different functionalities on the nanoparticle surface affect their interactions with SELP. The 50 nm nanoparticles in SELP exhibit chaining (linear association of the nanoparticles), while the 30 nm nanoparticles are too small and settle out of the polymer mesh and the 80 nm nanoparticles tend to cluster without any regard for SELP structure. The SELP concentration does not have a major affect on nanoparticle behavior in the nanocomposites.en_US
dc.identifier.urihttp://hdl.handle.net/1903/12683
dc.subject.pqcontrolledMaterials Scienceen_US
dc.subject.pquncontrollediron oxide nanoparticlesen_US
dc.subject.pquncontrolledsilk elastin-like protein polymeren_US
dc.subject.pquncontrolledsmall angle neutron scatteringen_US
dc.subject.pquncontrolledtransmission electron microscopyen_US
dc.subject.pquncontrolledvibrating sample magnetometryen_US
dc.titleCharacterization of Iron Oxide Nanoparticles in Structural Silk-elastinlike Protein Polymeren_US
dc.typeThesisen_US

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