Tissue-Targeted Drug Delivery Strategies to Promote Antigen-Specific Immune Tolerance

Simple item page
dc.contributor.authorRui, Yuan
dc.contributor.authorEppler, Haleigh B.
dc.contributor.authorYanes, Alexis A.
dc.contributor.authorJewell, Christopher M.
dc.date.accessioned2023-10-03T16:38:16Z
dc.date.available2023-10-03T16:38:16Z
dc.date.issued2022-11-23
dc.description.abstractDuring autoimmunity or organ transplant rejection, the immune system attacks host or transplanted tissue, causing debilitating inflammation for millions of patients. There is no cure for most of these diseases. Further, available therapies modulate inflammation through nonspecific pathways, reducing symptoms but also compromising patients’ ability to mount healthy immune responses. Recent preclinical advances to regulate immune dysfunction with vaccine-like antigen specificity reveal exciting opportunities to address the root cause of autoimmune diseases and transplant rejection. Several of these therapies are currently undergoing clinical trials, underscoring the promise of antigen-specific tolerance. Achieving antigen-specific tolerance requires precision and often combinatorial delivery of antigen, cytokines, small molecule drugs, and other immunomodulators. This can be facilitated by biomaterial technologies, which can be engineered to orient and display immunological cues, protect against degradation, and selectively deliver signals to specific tissues or cell populations. In this review, some key immune cell populations involved in autoimmunity and healthy immune tolerance are described. Opportunities for drug delivery to immunological organs are discussed, where specialized tissue-resident immune cells can be programmed to respond in unique ways toward antigens. Finally, cell- and biomaterial-based therapies to induce antigen-specific immune tolerance that are currently undergoing clinical trials are highlighted.
dc.description.urihttps://doi.org/10.1002/adhm.202202238
dc.identifierhttps://doi.org/10.13016/dspace/fzkt-ql4m
dc.identifier.citationRui, Y., Eppler, H. B., Yanes, A. A., Jewell, C. M., Tissue-Targeted Drug Delivery Strategies to Promote Antigen-Specific Immune Tolerance. Adv. Healthcare Mater. 2023, 12, 2202238.
dc.identifier.urihttp://hdl.handle.net/1903/30656
dc.language.isoen_US
dc.publisherWiley
dc.relation.isAvailableAtA. James Clark School of Engineeringen_us
dc.relation.isAvailableAtFischell Department of Bioengineeringen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectautoimmunity
dc.subjectbiomaterials
dc.subjectdrug delivery
dc.subjectimmune tolerance
dc.subjectimmunotherapy
dc.subjectnanoparticles and microparticles
dc.titleTissue-Targeted Drug Delivery Strategies to Promote Antigen-Specific Immune Tolerance
dc.typeArticle
local.equitableAccessSubmissionNo

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Adv Healthcare Materials - 2022 - Rui - Tissue‐Targeted Drug Delivery Strategies to Promote Antigen‐Specific Immune.pdf
Size:
3.37 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.55 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Fischell Department of Bioengineering Research Works