Anti-Adipogenic Activity of High-Phenolic Sorghum Brans in Pre-Adipocytes

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dc.contributor.authorLee, Hee-Seop
dc.contributor.authorSantana, Ádina L.
dc.contributor.authorPeterson, Jaymi
dc.contributor.authorYucel, Umut
dc.contributor.authorPerumal, Ramasamy
dc.contributor.authorDe Leon, Joaquin
dc.contributor.authorLee, Seong-Ho
dc.contributor.authorSmolensky, Dmitriy
dc.date.accessioned2023-10-25T18:23:34Z
dc.date.available2023-10-25T18:23:34Z
dc.date.issued2022-04-02
dc.description.abstractObesity is one of the leading public health problems that can result in life-threatening metabolic and chronic diseases such as cardiovascular diseases, diabetes, and cancer. Sorghum (Sorghum bicolor (L.) Moench) is the fifth most important cereal crop in the world and certain genotypes of sorghum have high polyphenol content. PI570481, SC84, and commercially available sumac sorghum are high-polyphenol genotypes that have demonstrated strong anti-cancer activities in previous studies. The objective of this study was to explore a potential anti-obesity use of extracts from sorghum bran in the differentiation of 3T3-L1 preadipocytes and to investigate cellular and molecular responses in differentiated adipocytes to elucidate related mechanisms. None of the four different sorghum bran extracts (PI570481, SC84, Sumac, and white sorghum as a low-polyphenol control) caused cytotoxicity in undifferentiated and differentiated 3T3-L1 cells at doses used in this study. Sorghum bran extracts (PI570481, SC84, and Sumac) reduced intracellular lipid accumulation and expression of adipogenic and lipogenic proteins in a dose-dependent manner in differentiated 3T3-L1 cells. The same polyphenol containing sorghum bran extracts also repressed production of reactive oxygen species (ROS) and MAPK signaling pathways and repressed insulin signaling and glucose uptake in differentiated 3T3-L1 cells. These data propose a potential use of high-phenolic sorghum bran for the prevention of obesity.
dc.description.urihttps://doi.org/10.3390/nu14071493
dc.identifierhttps://doi.org/10.13016/dspace/cfp4-bq7m
dc.identifier.citationLee, H.-S.; Santana, Á.L.; Peterson, J.; Yucel, U.; Perumal, R.; De Leon, J.; Lee, S.-H.; Smolensky, D. Anti-Adipogenic Activity of High-Phenolic Sorghum Brans in Pre-Adipocytes. Nutrients 2022, 14, 1493.
dc.identifier.urihttp://hdl.handle.net/1903/31121
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtCollege of Agriculture & Natural Resourcesen_us
dc.relation.isAvailableAtNutrition & Food Scienceen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjecthigh-phenolic sorghum bran
dc.subjectadipogenesis
dc.subjectlipogenesis
dc.subject3T3-L1
dc.subjectpolyphenols
dc.titleAnti-Adipogenic Activity of High-Phenolic Sorghum Brans in Pre-Adipocytes
dc.typeArticle
local.equitableAccessSubmissionNo

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