NEW METHODOLOGY TO IDENTIFY POTENTIAL ENVIRONMENTAL TRIGGERS FOR ANCA-ASSOCIATED VASCULITIDES

dc.contributor.advisorMilton, Donald K.en_US
dc.contributor.authorBeins, Kaley Elizabethen_US
dc.contributor.departmentMaryland Institute for Applied Environmental Healthen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2018-09-13T05:36:08Z
dc.date.available2018-09-13T05:36:08Z
dc.date.issued2018en_US
dc.description.abstractA series of rare autoimmune disorders that affect the blood vessels, vasculitis is chronic and potentially deadly. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprise three diagnostic forms of this autoimmune disorder: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA or Churg-Strauss syndrome). The limited resources available to vasculitis researchers have been mostly targeted toward treatment and relapse prediction with a small amount of research examining genetic and environmental etiologic factors. Therefore, additional research is needed to understand the role of gene-environment interactions in AAV etiology. This thesis reviews the current body of AAV literature with a focus on candidate genes, occupational and environmental exposures, and the hygiene hypothesis. It also designs an original survey and study methodology to further investigate these etiologic factors. A better understanding of AAV etiology will lead to prevention and improved treatment of these costly diseases.en_US
dc.identifierhttps://doi.org/10.13016/M2DV1CR94
dc.identifier.urihttp://hdl.handle.net/1903/21338
dc.language.isoenen_US
dc.subject.pqcontrolledEnvironmental healthen_US
dc.subject.pqcontrolledImmunologyen_US
dc.subject.pqcontrolledEpidemiologyen_US
dc.subject.pquncontrolledANCAen_US
dc.subject.pquncontrolledetiologyen_US
dc.subject.pquncontrolledexposureen_US
dc.subject.pquncontrolledoccupationen_US
dc.subject.pquncontrolledvasculitisen_US
dc.titleNEW METHODOLOGY TO IDENTIFY POTENTIAL ENVIRONMENTAL TRIGGERS FOR ANCA-ASSOCIATED VASCULITIDESen_US
dc.typeThesisen_US

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