Electronic Supporting Data: Acyclic Cucurbituril as Sequestrant for Acetaminophen
| dc.contributor.advisor | Isaacs, Lyle | |
| dc.contributor.author | Mogensen, Jeppe S. | |
| dc.contributor.author | Hofmann, Thomas M. | |
| dc.contributor.author | Perera, Suvenika | |
| dc.contributor.author | Lie, Yann | |
| dc.contributor.author | Pittelkow, Michael | |
| dc.contributor.author | Isaacs, Lyle | |
| dc.date.accessioned | 2026-05-07T15:08:06Z | |
| dc.date.issued | 2026-01-01 | |
| dc.description | See the read me file and the main publication. | |
| dc.description.abstract | We report that acyclic CB[n]-type host H4 functions as a solid state sequestrant for pharmaceutical micropollutants (PMs) from water (acetaminophen, phenol, propranolol, ibuprofen and citalopram), reaching up to 99.8% removal efficiency within 5 minutes. A head-to-head study shows H4 performs at least as well as activated charcoal (DARCO®) at sequestering acetaminophen from simulated gastric fluid. The structure of H4•acetaminophen determined by micro electron-diffraction substantiates the geometry of the cavity inclusion complex. | |
| dc.description.sponsorship | L.I., S.P. and T.M.H. thank the National Institutes of Health (R35GM153362) and the University of Maryland for financial support. M.P., Y.L., and J.S.M. thank the Novo Nordisk foundation (NNF24OC0090256 and NNF21OC0072067), the Lundbeck foundation and the University of Copenhagen for financial support. Electron diffraction experiments are supported by the Novo Nordisk Foundation Research Infrastructure grant no. NNF220C0074439. | |
| dc.identifier | https://doi.org/10.13016/yuud-ag8i | |
| dc.identifier.citation | Chemical Communications 2026, 62, in press | |
| dc.identifier.uri | http://hdl.handle.net/1903/35285 | |
| dc.language.iso | en_US | |
| dc.publisher | Royal Society of Chemistry | |
| dc.relation.isAvailableAt | Digital Repository at the University of Maryland | en_us |
| dc.relation.isAvailableAt | Chemistry & Biochemistry | en_us |
| dc.relation.isAvailableAt | College of Computer, Mathematical & Natural Sciences | en_us |
| dc.relation.isAvailableAt | University of Maryland (College Park, MD) | en_us |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
| dc.subject | acyclic cucurbituril | |
| dc.subject | solid state sequestrant | |
| dc.subject | acetaminophen | |
| dc.title | Electronic Supporting Data: Acyclic Cucurbituril as Sequestrant for Acetaminophen | |
| dc.type | Other |