Connectivity based parcellation and brain atlas generation - extracting connectome information for Schizophrenia research

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dc.contributor.advisorJaJa, Joseph F.en_US
dc.contributor.authorWang, Qien_US
dc.contributor.departmentElectrical Engineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2014-10-16T05:36:50Z
dc.date.available2014-10-16T05:36:50Z
dc.date.issued2014en_US
dc.description.abstractTraditional brain atlases are mainly based on hand-crafted anatomical structures, ignoring the useful connectivity pattern information. In our work we use diffusion weighted imaging data to incorporate connectivity information into atlas generation. We use FSL to process the data to extract the connectivity matrix. The brain parcellation problem is then formulated as a min-cut problem on a big, sparse graph. Spectral clustering and an original multi-class Hopfield network (MHN) method is applied to solve the problem, each working with a different analytical framework: MHN works in the diffusion space to generate individual parcellations, while spectral clustering works on standard space averaged connectome to generate group level atlases. Group study of brain images with Schizophrenia is conducted, showing significant improvement in accuracy for disease diagnosis using features extracted with the proposed parcellation scheme. Hypothesis test was performed on local structures to explore possible structural causes of the disease.en_US
dc.identifierhttps://doi.org/10.13016/M2P590
dc.identifier.urihttp://hdl.handle.net/1903/15899
dc.language.isoenen_US
dc.subject.pqcontrolledComputer scienceen_US
dc.subject.pqcontrolledNeurosciencesen_US
dc.subject.pquncontrolledconnectomeen_US
dc.subject.pquncontrolledDiffusion weighted imageen_US
dc.subject.pquncontrolledmulti-class Hopfield networken_US
dc.subject.pquncontrolledparcellationen_US
dc.titleConnectivity based parcellation and brain atlas generation - extracting connectome information for Schizophrenia researchen_US
dc.typeThesisen_US

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