Modulation of early olfactory circuits by long-range GABAergic inhibition

dc.contributor.advisorAraneda, Ricardo Cen_US
dc.contributor.authorVillar Del Rio, Pablo Sebastianen_US
dc.contributor.departmentBiologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2022-06-21T05:35:52Z
dc.date.available2022-06-21T05:35:52Z
dc.date.issued2022en_US
dc.description.abstractSensory perception emerges from the interplay between stimulus-driven feedforward cortical activation and feedback signals that sculpt the activity of early sensory circuits. Odor information is first processed in the olfactory bulb and the activity of its circuits is flexibly shaped by descending signals that arise in several brain regions, including neurons in the basal forebrain (BF). Among these neurons, a group of GABAergic neurons in the BF can modulate odor processing, however, how is this achieved is unknown. Here, we investigate how the activity of long-range GABAergic neurons in the BF modulate the spatiotemporal dynamics of the bulb output neurons. To examine the odor evoked responses of GABAergic neurons, we monitor the activity of their axons in the olfactory bulb of awake mice and characterize their response as a function of odor identity and concentration, using multiphoton calcium imaging. In addition, we provide anatomical and functional evidence for the existence of a feedback loop that is able to recruit GABAergic neurons in the BF through direct glutamatergic inputs originating in the olfactory cortex. Our work underscores basic principles on how stimulus-driven feedforward information recruits higher-order brain regions to provide descending feedback signals capable of shaping the output of early sensory processing stages.en_US
dc.identifierhttps://doi.org/10.13016/8dzi-xmbo
dc.identifier.urihttp://hdl.handle.net/1903/28929
dc.language.isoenen_US
dc.subject.pqcontrolledNeurosciencesen_US
dc.subject.pquncontrolledbasal forebrainen_US
dc.subject.pquncontrolledMagnocellular preoptic areaen_US
dc.subject.pquncontrolledOlfactory bulben_US
dc.subject.pquncontrolledolfactory processingen_US
dc.titleModulation of early olfactory circuits by long-range GABAergic inhibitionen_US
dc.typeDissertationen_US

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