THE EFFECT OF RESVERATROL ON PROSTATE CANCER PREVENTION

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dc.contributor.advisorMagnuson, Bernadene A.en_US
dc.contributor.advisorWang, Thomas T.Y.en_US
dc.contributor.authorWang, TIEN-CHUNGen_US
dc.contributor.departmentNutritionen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2006-06-14T06:05:38Z
dc.date.available2006-06-14T06:05:38Z
dc.date.issued2006-05-05en_US
dc.description.abstractEpidemiological as well as in vitro studies generally support a beneficial effect for consumption of fruits and vegetables in preventing prostate cancer. This leads to the hypothesis that phytochemicals in fruits and vegetables may contribute to cancer prevention. Resveratrol has been proposed as a prostate cancer preventive candidate. However, relatively little is known of the molecular targets in prostate as well as mechanisms may contribute to prevent prostate cancer. This thesis attempted to elucidate the molecular effects and the mechanisms of resveratrol underlying the prostate cancer preventive effect. Our results indicated resveratrol exerts inhibitory effects on the growth of androgen-responsive human prostate cancer cell, LNCaP. At the molecular level, we found resveratrol inhibited androgen-responsive genes through both androgen- and estrogen-mediated events. Moreover, resveratrol regulates the IGF-1 pathway through regulation of androgen- and estrogen-mediated events. These results provide the molecular basis to support the potential prostate cancer preventive effect of resveratrol.en_US
dc.format.extent417185 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/3590
dc.language.isoen_US
dc.subject.pqcontrolledHealth Sciences, Nutritionen_US
dc.subject.pquncontrolledResveratrolen_US
dc.subject.pquncontrolledprostateen_US
dc.subject.pquncontrolledLNCaPen_US
dc.subject.pquncontrolledphytoestrogenen_US
dc.subject.pquncontrolledARGen_US
dc.subject.pquncontrolledIGF-1en_US
dc.titleTHE EFFECT OF RESVERATROL ON PROSTATE CANCER PREVENTIONen_US
dc.typeThesisen_US

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