THE EFFECTS OF OBESITY ON PLASMA LEVELS OF OMENTIN, A DEPOT-SPECIFIC ADIPOCYTOKINE

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dc.contributor.advisorKantor, Marken_US
dc.contributor.advisorMcLenithan, Johnen_US
dc.contributor.authorde Souza Batista, Celia Mariaen_US
dc.contributor.departmentNutritionen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2004-10-09T05:19:05Z
dc.date.available2004-10-09T05:19:05Z
dc.date.issued2004-08-27en_US
dc.description.abstractObesity is a chronic pathological condition and a risk factor for diabetes and cardiovascular disease. It has been demonstrated that adipose tissue functions not only as a fat storage depot but also as an endocrine organ. Omentin is a protein expressed and secreted in adipose tissue that increases insulin-stimulated glucose transport. To further elucidate omentin's physiological function, its levels were measured by quantitative western blotting in plasma from 44 healthy nondiabetic volunteers (22 women, 22 men). Participants were organized into sibling pairs based on discordant BMI (3-12 Kg/m2). Lean subjects had significantly higher omentin levels than obese/overweight subjects (independent of sex), and significantly higher omentin levels were detected in women compared to men. Omentin levels were inversely correlated with BMI and positively correlated with HDL levels. These data suggest that omentin may play a physiological role in the pathogenesis of obesity-dependent insulin resistance.en_US
dc.format.extent1138066 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/1884
dc.language.isoen_US
dc.subject.pqcontrolledHealth Sciences, Nutritionen_US
dc.subject.pqcontrolledBiology, Cellen_US
dc.subject.pqcontrolledBiology, Molecularen_US
dc.subject.pquncontrolledomentinen_US
dc.subject.pquncontrolledadipose tissueen_US
dc.subject.pquncontrolledadipocytokinesen_US
dc.subject.pquncontrolledobesityen_US
dc.subject.pquncontrolledmetabolic syndromeen_US
dc.titleTHE EFFECTS OF OBESITY ON PLASMA LEVELS OF OMENTIN, A DEPOT-SPECIFIC ADIPOCYTOKINEen_US
dc.typeThesisen_US

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