MODE OF BIRTH AND VAGINAL MICROBIOTA IN REPRODUCTIVE-AGE WOMEN

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dc.contributor.advisorDyerà!o, Typhanyeen_US
dc.contributor.authorStennett, Christinaen_US
dc.contributor.departmentEpidemiology and Biostatisticsen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2017-09-13T05:31:59Z
dc.date.available2017-09-13T05:31:59Z
dc.date.issued2017en_US
dc.description.abstractIt is well documented that women with robust, Lactobacillus-dominated vaginal microbiotas are less likely to develop a range of adverse reproductive health outcomes. The birthing process is thought to be a critical event in the initial seeding, or colonization, of the human microbiome, and the transfer of microbiota from mother to baby during delivery is associated with long-term health. We recruited 88 adult women to a cross-sectional study to evaluate the relationship between their vaginal microbiota and the mode of their birth (self-reported as vaginal delivery or Cesarean section (C-section)). In a multivariable analysis, women who had a less protective, low-Lactobacillus community state type had 3-fold increased odds of having been born via C-section, indicating that C-section is related to vaginal dysbiosis in adulthood (adjusted OR: 3.73, p=0.01, 95% CI: 1.08-12.77). Although the cross-sectional analysis does not account for fluctuations in microbial composition, the significant point estimate suggests that birth mode may play a role in vaginal seeding and colonization outcomes in adult women.en_US
dc.identifierhttps://doi.org/10.13016/M2R20RW98
dc.identifier.urihttp://hdl.handle.net/1903/19767
dc.language.isoenen_US
dc.subject.pqcontrolledEpidemiologyen_US
dc.subject.pquncontrolledbirth modeen_US
dc.subject.pquncontrolledc-sectionen_US
dc.subject.pquncontrolledvaginal microbiotaen_US
dc.titleMODE OF BIRTH AND VAGINAL MICROBIOTA IN REPRODUCTIVE-AGE WOMENen_US
dc.typeThesisen_US

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