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    COMPARING LEVELS OF NDH-1 DEHYDROGENASE ACTIVITY IN DIFFERENT MYCOBACTERIAL SPECIES.

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    No. of downloads: 747

    Date
    2008
    Author
    Azogue, Sharon
    Advisor
    Briken, Volker
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    Abstract
    The nuoG gene of Mycobacterium tuberculosis (Mtb) has the ability to inhibit host cell apoptosis. This ability is a virulence factor and does not exist in facultative pathogenic and non-pathogenic mycobacterial species. NuoG is part of the NDH-1 complex, and this study addressed the potential link between the role of NuoG in apoptosis inhibition and the biochemical activity of the NDH-1 complex. Different mycobacterial species were tested for their NDH-1 activities. Among the bacteria tested were bacteria transformed with the Mtb nuoG plasmid, or with the almost entire NDH-1 coding region. Surprisingly, the levels of NDH-1 activity did not correlate with apoptosis levels, suggesting a potential independent, novel mechanism by which NuoG inhibits host cell apoptosis.
    URI
    http://hdl.handle.net/1903/9207
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    • Cell Biology & Molecular Genetics Theses and Dissertations
    • UMD Theses and Dissertations

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    DRUM is brought to you by the University of Maryland Libraries
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