COMPARING LEVELS OF NDH-1 DEHYDROGENASE ACTIVITY IN DIFFERENT MYCOBACTERIAL SPECIES.
| dc.contributor.advisor | Briken, Volker | en_US |
| dc.contributor.author | Azogue, Sharon | en_US |
| dc.contributor.department | Cell Biology & Molecular Genetics | en_US |
| dc.contributor.publisher | Digital Repository at the University of Maryland | en_US |
| dc.contributor.publisher | University of Maryland (College Park, Md.) | en_US |
| dc.date.accessioned | 2009-07-02T05:54:13Z | |
| dc.date.available | 2009-07-02T05:54:13Z | |
| dc.date.issued | 2008 | en_US |
| dc.description.abstract | The nuoG gene of Mycobacterium tuberculosis (Mtb) has the ability to inhibit host cell apoptosis. This ability is a virulence factor and does not exist in facultative pathogenic and non-pathogenic mycobacterial species. NuoG is part of the NDH-1 complex, and this study addressed the potential link between the role of NuoG in apoptosis inhibition and the biochemical activity of the NDH-1 complex. Different mycobacterial species were tested for their NDH-1 activities. Among the bacteria tested were bacteria transformed with the Mtb nuoG plasmid, or with the almost entire NDH-1 coding region. Surprisingly, the levels of NDH-1 activity did not correlate with apoptosis levels, suggesting a potential independent, novel mechanism by which NuoG inhibits host cell apoptosis. | en_US |
| dc.format.extent | 7021271 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/1903/9207 | |
| dc.language.iso | en_US | |
| dc.subject.pqcontrolled | Biology, Microbiology | en_US |
| dc.subject.pqcontrolled | Chemistry, Biochemistry | en_US |
| dc.title | COMPARING LEVELS OF NDH-1 DEHYDROGENASE ACTIVITY IN DIFFERENT MYCOBACTERIAL SPECIES. | en_US |
| dc.type | Thesis | en_US |
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