COMPARING LEVELS OF NDH-1 DEHYDROGENASE ACTIVITY IN DIFFERENT MYCOBACTERIAL SPECIES.

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dc.contributor.advisorBriken, Volkeren_US
dc.contributor.authorAzogue, Sharonen_US
dc.contributor.departmentCell Biology & Molecular Geneticsen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2009-07-02T05:54:13Z
dc.date.available2009-07-02T05:54:13Z
dc.date.issued2008en_US
dc.description.abstractThe nuoG gene of Mycobacterium tuberculosis (Mtb) has the ability to inhibit host cell apoptosis. This ability is a virulence factor and does not exist in facultative pathogenic and non-pathogenic mycobacterial species. NuoG is part of the NDH-1 complex, and this study addressed the potential link between the role of NuoG in apoptosis inhibition and the biochemical activity of the NDH-1 complex. Different mycobacterial species were tested for their NDH-1 activities. Among the bacteria tested were bacteria transformed with the Mtb nuoG plasmid, or with the almost entire NDH-1 coding region. Surprisingly, the levels of NDH-1 activity did not correlate with apoptosis levels, suggesting a potential independent, novel mechanism by which NuoG inhibits host cell apoptosis.en_US
dc.format.extent7021271 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/9207
dc.language.isoen_US
dc.subject.pqcontrolledBiology, Microbiologyen_US
dc.subject.pqcontrolledChemistry, Biochemistryen_US
dc.titleCOMPARING LEVELS OF NDH-1 DEHYDROGENASE ACTIVITY IN DIFFERENT MYCOBACTERIAL SPECIES.en_US
dc.typeThesisen_US

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